ENSDARG00000008186


Danio rerio

Features
Gene ID: ENSDARG00000008186
  
Biological name :syk
  
Synonyms : spleen tyrosine kinase / syk
  
Possible biological names infered from orthology : P43405 / P48025 / spleen associated tyrosine kinase
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 5533843
Gene end: 5581487
  
Corresponding Affymetrix probe sets: DrAffx.1.11.S1_at (Zebrafish Array)   NM_212843_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003321
Ensembl peptide - ENSDARP00000132135
Ensembl peptide - ENSDARP00000122788
NCBI entrez gene - 405769     See in Manteia.
RefSeq - NM_212843
RefSeq - XM_021479147
RefSeq Peptide - NP_998008
swissprot - F1QFN4
swissprot - E9QFU7
swissprot - A0A0R4IBB3
ZFIN ID - ZDB-GENE-040702-3
Ensembl - ENSDARG00000008186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYKENSGALG00000015216Gallus gallus
 SYKENSG00000165025Homo sapiens
 SykENSMUSG00000021457Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*ENSDARG0000001575253
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *ENSDARG0000002629425
si:ch73-383l1.1ENSDARG0000009040825
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000000467224
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000003699324
erbb4a / erb-b2 receptor tyrosine kinase 4aENSDARG0000006320724
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000000620222
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000002284122
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000003957722
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000009064621
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000010440920
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *ENSDARG0000006943319
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000010045619
erbb4b / erb-b2 receptor tyrosine kinase 4bENSDARG0000008953618
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSDARG000000569098
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...ENSDARG000000138477


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012234  Tyrosine-protein kinase, non-receptor SYK/ZAP-70
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR023420  Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0002281 macrophage activation involved in immune response IBA
 biological_processGO:0002283 neutrophil activation involved in immune response IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0043306 positive regulation of mast cell degranulation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045579 positive regulation of B cell differentiation IBA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0090330 regulation of platelet aggregation IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Integrin alphaIIb beta3 signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel decreased length , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel morphology , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct aplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000068763 plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSDARG00000004433 btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *  / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000103276 fcer1g / Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide / P20491* / P30273* / Fc fragment of IgE receptor Ig* / High affinity immunoglobulin epsilon receptor subunit gamma *  / complex / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000094894 tyrobp / TYRO protein tyrosine kinase binding protein / O43914* / O54885*  / complex / reaction
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction






 

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