ENSDARG00000008867


Danio rerio

Features
Gene ID: ENSDARG00000008867
  
Biological name :rap1b
  
Synonyms : Q6TEN1 / rap1b / RAP1B, member of RAS oncogene family
  
Possible biological names infered from orthology : P61224 / Q99JI6 / RAS related protein 1b
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 18852821
Gene end: 18939338
  
Corresponding Affymetrix probe sets: Dr.3628.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000042249
Ensembl peptide - ENSDARP00000114387
swissprot - Q6TEN1
swissprot - Z4YIG5
ZFIN ID - ZDB-GENE-030131-9662
Ensembl - ENSDARG00000008867
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAP1BENSGALG00000009927Gallus gallus
 RAP1BENSG00000127314Homo sapiens
 Rap1bENSMUSG00000052681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*ENSDARG0000001255393
rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*ENSDARG0000008734693
rap2c / RAP2C, member of RAS oncogene family / Q8BU31* / Q9Y3L5* / Ras-related protein Rap-2c *ENSDARG0000001564961
rap2aa / RAP2A, member of RAS oncogene family aENSDARG0000007755361
rap2b / RAP2B, member of RAS oncogene family / P61225* / P61226*ENSDARG0000010303261
rap2ab / RAP2A, member of RAS oncogene family bENSDARG0000004024660
rit1 / Ras-like without CAAX 1 / P70426* / Q92963* / GTP-binding protein Rit1 *ENSDARG0000006915046
diras1b / DIRAS family, GTP-binding RAS-like 1b / Q91Z61* / O95057* / DIRAS1* / DIRAS family GTPase 1* / GTP-binding protein Di-Ras1 *ENSDARG0000000937240
diras1a / DIRAS family, GTP-binding RAS-like 1a / Q91Z61* / O95057* / DIRAS1* / DIRAS family GTPase 1* / GTP-binding protein Di-Ras1 *ENSDARG0000002806640
rasd1 / RAS, dexamethasone-induced 1 / Q9Y272* / O35626* / ras related dexamethasone induced 1* / Dexamethasone-induced Ras-related protein 1 *ENSDARG0000001927439
rasd4 / rasd family member 4ENSDARG0000009923839
rasd3 / RASD family member 3ENSDARG0000005846435
si:dkey-27j5.5ENSDARG0000002638333
zgc:114118ENSDARG0000005222233
rasl10a / RAS-like, family 10, member AENSDARG0000006231428
RASL10B / RAS like family 10 member B / Q96S79*ENSDARG0000010943615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0003428 chondrocyte intercalation involved in growth plate cartilage morphogenesis IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0032525 somite rostral/caudal axis specification IGI
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060536 cartilage morphogenesis IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IGI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
MET activates RAP1 and RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000060 prechordal plate prechordal plate structure , abnormal
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 ZFA:0000092 axis axis increased width , abnormal
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 ZFA:0000107 eye eye position , abnormal
eye fused with eye , abnormal
eye decreased amount , abnormal
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 ZFA:0000132 neural plate neural plate increased width , abnormal
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 ZFA:0000135 notochord notochord increased width , abnormal
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 ZFA:0000155 somite somite shape , abnormal
somite size , abnormal
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 ZFA:0001058 caudal fin caudal fin morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism increased curvature , abnormal
whole organism anterior-posterior axis truncated , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0009000 cell cell accumulation tail bud dorsal side, abnormal
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 ZFA:0009065 endothelial cell endothelial cell cell-cell junction absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction
 ENSDARG00000062328 rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated) / Q7LDG7* / Q9QUG9* / RAS guanyl releasing protein 2*  / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000053272 si:dkey-166d12.2 / P47736* / RAP1GAP* / RAP1 GTPase activating protein*  / reaction
 ENSDARG00000061551 rap1gap2a / RAP1 GTPase activating protein 2a / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*  / reaction
 ENSDARG00000079291 rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3 / Q8VCC8* / O95398* / Rap guanine nucleotide exchange factor 3* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapge...  / reaction
 ENSDARG00000076697 zmp:0000001168 / SIPA1* / Q96FS4* / signal-induced proliferation-associated 1*  / reaction






 

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