ENSDARG00000056525


Danio rerio

Features
Gene ID: ENSDARG00000056525
  
Biological name :bcar1
  
Synonyms : bcar1 / breast cancer anti-estrogen resistance 1
  
Possible biological names infered from orthology : BCAR1, Cas family scaffolding protein / Breast cancer anti-estrogen resistance protein 1 / P56945 / Q61140
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 22504200
Gene end: 22688073
  
Corresponding Affymetrix probe sets: Dr.13178.1.A1_at (Zebrafish Array)   Dr.4707.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000151072
Ensembl peptide - ENSDARP00000152559
Ensembl peptide - ENSDARP00000151884
Ensembl peptide - ENSDARP00000106517
Ensembl peptide - ENSDARP00000144076
Ensembl peptide - ENSDARP00000147960
NCBI entrez gene - 568309     See in Manteia.
RefSeq - NM_001135133
RefSeq Peptide - NP_001128605
swissprot - B5DE36
swissprot - A0A286YA76
ZFIN ID - ZDB-GENE-030131-2774
Ensembl - ENSDARG00000056525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCAR1ENSGALG00000042895Gallus gallus
 BCAR1ENSG00000050820Homo sapiens
 Bcar1ENSMUSG00000031955Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nedd9 / neural precursor cell expressed, developmentally down-regulated 9 / O35177* / Q14511* / neural precursor cell expressed, developmentally down-regulated gene 9*ENSDARG0000008987836
cass4 / Cas scaffolding protein family member 4 / Q08EC4* / Q9NQ75*ENSDARG0000000677522
efs / embryonal Fyn-associated substrate / O43281* / Q64355*ENSDARG0000008883520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR014928  Serine rich protein interaction domain
 IPR021901  CAS family, C-terminal
 IPR028848  Breast cancer anti-estrogen resistance protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction






 

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