ENSDARG00000103542


Danio rerio

Features
Gene ID: ENSDARG00000103542
  
Biological name :vegfaa
  
Synonyms : O73682 / vascular endothelial growth factor Aa / vegfaa
  
Possible biological names infered from orthology : P15692 / Q00731 / vascular endothelial growth factor A / VEGFA
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 4287542
Gene end: 4317879
  
Corresponding Affymetrix probe sets: Dr.597.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000133415
NCBI entrez gene - 30682     See in Manteia.
swissprot - O73682
ZFIN ID - ZDB-GENE-990415-273
Ensembl - ENSDARG00000103542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFAENSGALG00000010290Gallus gallus
 VEGFAENSG00000112715Homo sapiens
 VegfaENSMUSG00000023951Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vegfab / vascular endothelial growth factor Ab / VEGFA* / P15692* / Q00731* / vascular endothelial growth factor A*ENSDARG0000003470055
vegfba / vascular endothelial growth factor Ba / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009099735
pgfb / placental growth factor b / PGF* / P49764* / P49763* / placental growth factor*ENSDARG0000007676731
CABZ01077555.1 / PGF* / P49763* / placental growth factor*ENSDARG0000011535922
vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009248015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
 biological_processGO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation IGI
 biological_processGO:0007202 activation of phospholipase C activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0031334 positive regulation of protein complex assembly ISS
 biological_processGO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting IMP
 biological_processGO:0035479 angioblast cell migration from lateral mesoderm to midline IMP
 biological_processGO:0043491 protein kinase B signaling IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISS
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 biological_processGO:1901342 regulation of vasculature development IGI
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IMP
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IBA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood increased accumulation post-vent region , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle decreased contractility , abnormal
cardiac ventricle non-contractile , abnormal
cardiac ventricle increased amount , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta broken , abnormal
dorsal aorta aplastic , abnormal
dorsal aorta decreased amount , abnormal
dorsal aorta absent , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000082 vein vein broken , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart regeneration decreased process quality , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein decreased size , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery malformed , abnormal
intersegmental artery branching involved in blood vessel morphogenesis decreased process quality , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type basilar artery , abnormal
whole organism lacks all parts of type central artery , abnormal
whole organism lacks all parts of type intersegmental vessel , abnormal
whole organism lacks all parts of type cerebellar central artery , abnormal
whole organism lacks all parts of type anterior mesencephalic central artery , abnormal
whole organism lacks all parts of type middle mesencephalic central artery , abnormal
whole organism lacks all parts of type posterior mesencephalic central artery , abnormal
whole organism lacks all parts of type axial blood vessel , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel increased length , abnormal
intersegmental vessel has fewer parts of type blood vessel endothelial cell , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel shortened , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel irregular spatial pattern , abnormal
intersegmental vessel non-functional , abnormal
intersegmental vessel truncated , abnormal
intersegmental vessel aplastic , abnormal
intersegmental vessel absent , abnormal
intersegmental vessel immature , abnormal
intersegmental vessel dorsal region branchiness , ameliorated
intersegmental vessel vascular sprouts amount , ameliorated
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 ZFA:0001286 caudal vein plexus caudal vein plexus malformed , abnormal
caudal vein plexus aplastic , abnormal
caudal vein plexus morphology , abnormal
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 ZFA:0001319 myocardium myocardium mislocalised , abnormal
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 ZFA:0001320 endocardium endocardium mislocalised , abnormal
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 ZFA:0005002 basilar artery basilar artery morphology , abnormal
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 ZFA:0005009 aortic arch 5 aortic arch 5 absent , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature branchiness , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel hypoplastic , abnormal
dorsal longitudinal anastomotic vessel aplastic , abnormal
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 ZFA:0005147 regenerating tissue regenerating tissue coronary vasculature development delayed , abnormal
regenerating tissue heart vasculature disorganized , abnormal
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 ZFA:0005249 vasculature vasculature decreased amount , abnormal
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 ZFA:0005604 angiogenic sprout angiogenic sprout absent , abnormal
angiogenic sprout physical object quality , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex
 ENSDARG00000089983 si:ch73-109i22.2 / Q9NP31* / Q9QXK9* / SH2D2A* / SH2 domain containing 2A*  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000058993 rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*  / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex / reaction
 ENSDARG00000019371 flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000062080 shc2 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / Q8BMC3* / SHC adaptor protein 2*  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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