ENSDARG00000018206


Danio rerio

Features
Gene ID: ENSDARG00000018206
  
Biological name :nck2a
  
Synonyms : nck2a / NCK adaptor protein 2a
  
Possible biological names infered from orthology : Cytoplasmic protein NCK2 / NCK2 / NCK adaptor protein 2 / O43639 / O55033
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 6393368
Gene end: 6502491
  
Corresponding Affymetrix probe sets: Dr.9538.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000093447
Ensembl peptide - ENSDARP00000136469
NCBI entrez gene - 393972     See in Manteia.
swissprot - A0A0R4IMX4
swissprot - F1R1C3
ZFIN ID - ZDB-GENE-040426-686
Ensembl - ENSDARG00000018206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCK2ENSGALG00000016799Gallus gallus
 NCK2ENSG00000071051Homo sapiens
 Nck2ENSMUSG00000066877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000004336175
nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007536964
nck1a / NCK adaptor protein 1a / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007426246
grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000000646814
grapb / GRB2-related adaptor protein b / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000002266814
grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000003805914
grapa / GRB2-related adaptor protein a / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000000541413
grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000010116913
grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000010527613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR035559  Nck2, SH3 domain 1
 IPR035561  Nck2, SH3 domain 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009967 positive regulation of signal transduction IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000001634 kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000039489 git1 / G protein-coupled receptor kinase interacting ArfGAP 1 / Q68FF6* / Q9Y2X7* / GIT ArfGAP 1* / ARF GTPase-activating protein GIT1 *  / complex / reaction
 ENSDARG00000056998 kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000060758 nphs1 / nephrosis 1, congenital, Finnish type (nephrin) / O60500* / Q9QZS7* / Nephrin * / NPHS1, nephrin*  / complex / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / complex / reaction
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / complex / reaction
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex / reaction
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex / reaction
 ENSDARG00000025326 myl12.2 / myosin, light chain 12, genome duplicate 2 / Q3THE2* / MYL12A* / MYL12B* / O14950* / P19105* / myosin light chain 12A* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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