ENSDARG00000060758


Danio rerio

Features
Gene ID: ENSDARG00000060758
  
Biological name :nphs1
  
Synonyms : nephrosis 1, congenital, Finnish type (nephrin) / nphs1
  
Possible biological names infered from orthology : Nephrin / NPHS1, nephrin / O60500 / Q9QZS7
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 36553823
Gene end: 36939655
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124320
Ensembl peptide - ENSDARP00000156407
Ensembl peptide - ENSDARP00000080406
NCBI entrez gene - 692352     See in Manteia.
RefSeq - NM_001040687
RefSeq Peptide - NP_001035777
swissprot - F1Q8Y5
swissprot - F8W3X9
ZFIN ID - ZDB-GENE-051102-1
Ensembl - ENSDARG00000060758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPHS1ENSG00000161270Homo sapiens
 Nphs1ENSMUSG00000006649Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*ENSDARG0000000163413
kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*ENSDARG0000005699813
kirrel3l / kirre like nephrin family adhesion molecule 3, like / Q7TSU7* / Q6UWL6* / KIRREL2* / Kin of IRRE-like protein 2 * / kirre like nephrin family adhesion molecule 2*ENSDARG0000010466513
kirrel3a / kirre like nephrin family adhesion molecule 3a / Q8IZU9* / Q8BR86* / KIRREL3* / kirre like nephrin family adhesion molecule 3* / Kin of IRRE-like protein 3 Processed kin of IRRE-...ENSDARG0000007580612
CABZ01073963.1 / Q8IZU9* / KIRREL3* / kirre like nephrin family adhesion molecule 3*ENSDARG0000011590310
CABZ01112461.1 / Q8IZU9* / KIRREL3* / kirre like nephrin family adhesion molecule 3*ENSDARG000001138333


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0039021 pronephric glomerulus development IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Nephrin family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
pericardium edematous , exacerbated
Show

 ZFA:0000106 extension extension edematous , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0001056 myotome myotome decreased width , abnormal
myotome malformed , abnormal
myotome muscle cell decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism curved dorsal , abnormal
whole organism decreased length , abnormal
whole organism decreased amount , abnormal
whole organism morphology , abnormal
whole organism dead , abnormal
whole organism morphology , exacerbated
whole organism dead , exacerbated
Show

 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus decreased size , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte cell projection morphology , abnormal
pronephric podocyte cell projection irregular spatial pattern , abnormal
pronephric podocyte cell projection increased area , abnormal
Show

 ZFA:0005309 pronephric glomerular capillary pronephric glomerular capillary hypotrophic , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell nucleus mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000001634 kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000042850 nphs2 / nephrosis 2, idiopathic, steroid-resistant (podocin) / Q9NP85* / Q91X05* / Podocin * / NPHS2, podocin*  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000056998 kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000060758 nphs1 / nephrosis 1, congenital, Finnish type (nephrin) / O60500* / Q9QZS7* / Nephrin * / NPHS1, nephrin*  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000104665 kirrel3l / kirre like nephrin family adhesion molecule 3, like / Q7TSU7* / Q6UWL6* / KIRREL2* / Kin of IRRE-like protein 2 * / kirre like nephrin family adhesion molecule 2*  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction






 

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