ENSDARG00000075369


Danio rerio

Features
Gene ID: ENSDARG00000075369
  
Biological name :nck1b
  
Synonyms : nck1b / NCK adaptor protein 1b
  
Possible biological names infered from orthology : Cytoplasmic protein NCK1 / NCK1 / NCK adaptor protein 1 / P16333 / Q99M51
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 3347510
Gene end: 3467044
  
Corresponding Affymetrix probe sets: Dr.17874.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000121375
Ensembl peptide - ENSDARP00000153435
NCBI entrez gene - 100334953     See in Manteia.
RefSeq - XM_002666595
swissprot - E7F6M0
ZFIN ID - ZDB-GENE-090317-1
Ensembl - ENSDARG00000075369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCK1ENSG00000158092Homo sapiens
 Nck1ENSMUSG00000032475Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000001820667
nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000004336166
nck1a / NCK adaptor protein 1a / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007426257
grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000000646815
grapa / GRB2-related adaptor protein a / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000000541414
grapb / GRB2-related adaptor protein b / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000002266814
grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000003805914
grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000010527614
grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000010116913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR034936  F-BAR and double SH3 domains protein
 IPR035562  Nck1, SH3 domain 1
 IPR035564  Nck1, SH3 domain 2
 IPR035565  Nck1, SH3 domain 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009967 positive regulation of signal transduction IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Nephrin family interactions
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000001634 kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000015149 wasa / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a / WAS* / P70315* / P42768* / Wiskott-Aldrich syndrome*  / reaction / complex
 ENSDARG00000022531 ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSDARG00000056998 kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000060758 nphs1 / nephrosis 1, congenital, Finnish type (nephrin) / O60500* / Q9QZS7* / Nephrin * / NPHS1, nephrin*  / complex / reaction
 ENSDARG00000045298 wipf2a / WAS/WASL interacting protein family, member 2a / WIPF2* / Q6PEV3* / Q8TF74* / WAS/WASL interacting protein family member 2*  / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000071084 wipf1b / WAS/WASL interacting protein family, member 1b / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000104300 wipf1a / WAS/WASL interacting protein family, member 1a / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000105112 ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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