ENSDARG00000022531


Danio rerio

Features
Gene ID: ENSDARG00000022531
  
Biological name :ntn1b
  
Synonyms : netrin 1b / ntn1b
  
Possible biological names infered from orthology : netrin 1 / NTN1 / O09118 / O95631
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 25708549
Gene end: 25814097
  
Corresponding Affymetrix probe sets: Dr.5785.1.S1_at (Zebrafish Array)   NM_130998_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000038885
Ensembl peptide - ENSDARP00000134866
NCBI entrez gene - 30192     See in Manteia.
RefSeq - NM_130998
RefSeq - XM_005171551
RefSeq - XM_005171552
RefSeq Peptide - NP_571073
swissprot - F1QUK5
ZFIN ID - ZDB-GENE-990415-168
Ensembl - ENSDARG00000022531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTN1ENSGALG00000023626Gallus gallus
 NTN1ENSG00000065320Homo sapiens
 Ntn1ENSMUSG00000020902Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*ENSDARG0000010511286
ntn2 / netrin 2 / NTN3* / O00634* / Q3UUG6* / Q9R1A3* / Tbc1d24* / netrin 3*ENSDARG0000007674866
ntn5 / netrin 5 / Q3UQ22* / Q8WTR8*ENSDARG0000003642242
ntng1a / netrin g1a / NTNG1* / Q8R4G0* / Q9Y2I2* / netrin G1*ENSDARG0000001497326
ush2a / Usher syndrome 2A (autosomal recessive, mild) / O75445* / Q2QI47* / usherin*ENSDARG0000002948226
ntng2a / netrin g2a / NTNG2* / Q8R4F1* / Q96CW9* / netrin G2*ENSDARG0000007736722
vav3b / vav 3 guanine nucleotide exchange factor b / NTNG1* / Q8R4G0* / Q9Y2I2* / netrin G1*ENSDARG0000007371320
ntng2b / netrin g2b / NTNG2* / Q8R4F1* / Q96CW9* / netrin G2*ENSDARG0000008710011
si:dkey-220k22.1ENSDARG0000003547110
si:ch211-158d24.2ENSDARG0000007853610
si:ch211-57i17.5 / MEGF9* / Q8BH27* / Q9H1U4* / multiple EGF like domains 9* / Multiple epidermal growth factor-like domains protein 9 *ENSDARG000000413750


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016358 dendrite development IGI
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IGI
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0030516 regulation of axon extension IGI
 biological_processGO:0071678 olfactory bulb axon guidance IMP
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
DCC mediated attractive signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001108 anterior commissure anterior commissure axon extension process quality , abnormal
Show

 ZFA:0001657 supraoptic tract supraoptic tract axon extension process quality , abnormal
Show

 ZFA:0009125 olfactory receptor cell olfactory receptor cell axon position , abnormal
olfactory receptor cell axon posterior to olfactory bulb , abnormal
olfactory receptor cell axon attached to medial protoglomerulus , abnormal
olfactory receptor cell axon attached to dorsal zone olfactory bulb , abnormal
olfactory receptor cell axon attached to anteromedial zone olfactory bulb , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron axon mislocalised medially , abnormal
dopaminergic neuron axon adjacent to hindbrain axis, abnormal
dopaminergic neuron axon adjacent to spinal cord axis, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000030871 siah1 / siah E3 ubiquitin protein ligase 1 / Siah1b* / Q8IUQ4* / P61092* / Siah1a* / siah E3 ubiquitin protein ligase 1B* / E3 ubiquitin-protein ligase SIAH1A *  / complex / reaction
 ENSDARG00000044381 siah2l / seven in absentia homolog 2 (Drosophila)-like / SIAH2* / SIAH3* / Q06986* / O43255* / Q8IW03* / siah E3 ubiquitin protein ligase 2* / siah E3 ubiquitin protein ligase family member 3*  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction






 

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