ENSDARG00000044381


Danio rerio

Features
Gene ID: ENSDARG00000044381
  
Biological name :siah2l
  
Synonyms : seven in absentia homolog 2 (Drosophila)-like / siah2l
  
Possible biological names infered from orthology : O43255 / Q06986 / Q8IW03 / SIAH2 / SIAH3 / siah E3 ubiquitin protein ligase 2 / siah E3 ubiquitin protein ligase family member 3
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 38659302
Gene end: 38717854
  
Corresponding Affymetrix probe sets: Dr.19234.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000065168
Ensembl peptide - ENSDARP00000099847
NCBI entrez gene - 378728     See in Manteia.
swissprot - B5DDM1
swissprot - G8JL17
ZFIN ID - ZDB-GENE-030922-1
Ensembl - ENSDARG00000044381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIAH2ENSGALG00000010395Gallus gallus
 SIAH3ENSGALG00000026849Gallus gallus
 SIAH2ENSG00000181788Homo sapiens
 SIAH3ENSG00000215475Homo sapiens
 Siah2ENSMUSG00000036432Mus musculus
 Siah3ENSMUSG00000091722Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
siah1 / siah E3 ubiquitin protein ligase 1 / Siah1b* / Q8IUQ4* / P61092* / Siah1a* / siah E3 ubiquitin protein ligase 1B* / E3 ubiquitin-protein ligase SIAH1A *ENSDARG0000003087166


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004162  E3 ubiquitin-protein ligase SIN-like
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018121  Seven-in-absentia protein, TRAF-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Ub-specific processing proteases
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite shape , abnormal
Show

 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism shortened , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000022531 ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000079198 usp13 / F1QFS9 / ubiquitin specific peptidase 13 / Q92995* / Q5BKP2* / ubiquitin specific peptidase 13 (isopeptidase T-3)*  / complex / reaction
 ENSDARG00000105112 ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr