ENSDARG00000073848


Danio rerio

Features
Gene ID: ENSDARG00000073848
  
Biological name :arhgef7b
  
Synonyms : arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b
  
Possible biological names infered from orthology : ARHGEF7 / Q14155 / Q9ES28 / Rho guanine nucleotide exchange factor 7
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 45958904
Gene end: 46020725
  
Corresponding Affymetrix probe sets: Dr.3987.1.A1_at (Zebrafish Array)   NM_001008624_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000100870
Ensembl peptide - ENSDARP00000042085
NCBI entrez gene - 494081     See in Manteia.
RefSeq - XM_017354718
RefSeq - NM_001008624
RefSeq Peptide - NP_001008624
swissprot - F1RE63
swissprot - F1QA07
ZFIN ID - ZDB-GENE-041212-49
Ensembl - ENSDARG00000073848
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF7ENSGALG00000031009Gallus gallus
 Q14155ENSG00000102606Homo sapiens
 Q9ES28ENSMUSG00000031511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG0000000629974
arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSDARG0000000668356
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000002592017
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000007843017
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG0000008778016
arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4 / Q7TNR9* / Q9NR80* / Rho guanine nucleotide exchange factor 4*ENSDARG0000001291415
prex2 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSDARG0000007169215
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG0000004471814
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG0000006283714
prex1 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSDARG0000007579314
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000006174613
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG0000007596213
arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000007862413
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG000000982338
si:ch73-383g2.1ENSDARG000000571075
si:dkey-21o19.2ENSDARG000000889004
CABZ01114581.1ENSDARG000001125263
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071896 protein localization to adherens junction IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
NRAGE signals death through JNK
Rho GTPase cycle
Ephrin signaling
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
brain hemorrhagic , abnormal
brain quality , abnormal
brain hemorrhagic , ameliorated
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 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure increased amount , abnormal
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 ZFA:0000076 swim bladder swim bladder decreased size , abnormal
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 ZFA:0000086 EVL EVL cell-cell adherens junction structure , abnormal
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 ZFA:0000099 brain vasculature brain vasculature broken , abnormal
brain vasculature has fewer parts of type central artery , abnormal
brain vasculature structure , abnormal
brain vasculature structure , ameliorated
brain vasculature increased fragility , abnormal
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 ZFA:0000113 head mesenchyme head mesenchyme position , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
heart decreased functionality , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000604 ventral aorta ventral aorta has fewer parts of type vascular associated smooth muscle cell , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel fragile , abnormal
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 ZFA:0001079 blood vasculature blood vasculature broken , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
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 ZFA:0001114 head head increased accumulation blood , abnormal
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 ZFA:0001261 ventricular system ventricular system hemorrhagic , abnormal
ventricular system increased accumulation blood , abnormal
ventricular system edematous , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature fragile , abnormal
cranial vasculature hemorrhagic , abnormal
cranial vasculature blood vessel endothelial cell morphology , abnormal
cranial vasculature blood vessel endothelial cell separated from head mesenchyme mesenchymal cell, abnormal
cranial vasculature morphology , abnormal
cranial vasculature immature , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal malformed , abnormal
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 ZFA:0005003 pharyngeal vasculature pharyngeal vasculature has fewer parts of type vascular associated smooth muscle cell , abnormal
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 ZFA:0005010 mid cerebral vein mid cerebral vein fragile , abnormal
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 ZFA:0005017 primordial midbrain channel primordial midbrain channel fragile , abnormal
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 ZFA:0005020 central artery central artery morphology , abnormal
central artery irregular spatial pattern , abnormal
central artery decreased length , abnormal
central artery unlumenized , abnormal
central artery structure , abnormal
central artery structure , ameliorated
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell cytoplasm decreased thickness , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte accumulation brain , abnormal
nucleate erythrocyte accumulation brain , ameliorated
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 ZFA:0009309 leukocyte leukocyte accumulation brain , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / complex / reaction
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex / reaction
 ENSDARG00000039489 git1 / G protein-coupled receptor kinase interacting ArfGAP 1 / Q68FF6* / Q9Y2X7* / GIT ArfGAP 1* / ARF GTPase-activating protein GIT1 *  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex / reaction
 ENSDARG00000025326 myl12.2 / myosin, light chain 12, genome duplicate 2 / Q3THE2* / MYL12A* / MYL12B* / O14950* / P19105* / myosin light chain 12A* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex






 

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