ENSDARG00000062080


Danio rerio

Features
Gene ID: ENSDARG00000062080
  
Biological name :shc2
  
Synonyms : shc2 / SHC (Src homology 2 domain containing) transforming protein 2
  
Possible biological names infered from orthology : P98077 / Q8BMC3 / SHC adaptor protein 2
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 21317597
Gene end: 21351469
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133114
Ensembl peptide - ENSDARP00000114455
NCBI entrez gene - 562011     See in Manteia.
RefSeq - NM_001044973
RefSeq Peptide - NP_001038438
swissprot - A0A0R4IEK8
swissprot - Q1LX18
ZFIN ID - ZDB-GENE-050208-666
Ensembl - ENSDARG00000062080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHC2ENSGALG00000001289Gallus gallus
 SHC2ENSG00000129946Homo sapiens
 Shc2ENSMUSG00000020312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *ENSDARG0000007543749
SHC3 / SHC adaptor protein 3 / Q92529*ENSDARG0000009890935


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029591  SHC-transforming protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Signalling to RAS
VEGFA-VEGFR2 Pathway
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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