ENSDARG00000034700


Danio rerio

Features
Gene ID: ENSDARG00000034700
  
Biological name :vegfab
  
Synonyms : vascular endothelial growth factor Ab / vegfab
  
Possible biological names infered from orthology : P15692 / Q00731 / vascular endothelial growth factor A / VEGFA
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 5568688
Gene end: 5597802
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101780
Ensembl peptide - ENSDARP00000120079
Ensembl peptide - ENSDARP00000120175
swissprot - F1QDN7
swissprot - F1QTG5
swissprot - Q5RHW5
ZFIN ID - ZDB-GENE-030131-4605
Ensembl - ENSDARG00000034700
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFAENSGALG00000010290Gallus gallus
 VEGFAENSG00000112715Homo sapiens
 VegfaENSMUSG00000023951Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*ENSDARG0000010354241
vegfba / vascular endothelial growth factor Ba / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009099726
pgfb / placental growth factor b / PGF* / P49764* / P49763* / placental growth factor*ENSDARG0000007676725
CABZ01077555.1 / PGF* / P49763* / placental growth factor*ENSDARG0000011535918
vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009248013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0002040 sprouting angiogenesis IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IBA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism lacks all parts of type basilar artery , abnormal
whole organism lacks all parts of type central artery , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein malformed , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte position , abnormal
nucleate erythrocyte mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr