ENSDARG00000028699


Danio rerio

Features
Gene ID: ENSDARG00000028699
  
Biological name :crkl
  
Synonyms : crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like
  
Possible biological names infered from orthology : Crk-like protein / CRK like proto-oncogene, adaptor protein / P46109 / P47941
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 18950575
Gene end: 18958079
  
Corresponding Affymetrix probe sets: Dr.830.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000037263
NCBI entrez gene - 556443     See in Manteia.
RefSeq - NM_213538
RefSeq Peptide - NP_998703
swissprot - Q6PH06
ZFIN ID - ZDB-GENE-040426-2951
Ensembl - ENSDARG00000028699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRKLENSGALG00000006390Gallus gallus
 CRKLENSG00000099942Homo sapiens
 CrklENSMUSG00000006134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*ENSDARG0000005563558


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035457  CRK, N-terminal SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007520 myoblast fusion IMP
 biological_processGO:0072114 pronephros morphogenesis IMP
 cellular_componentGO:0005575 cellular_component ND


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
NTRK2 activates RAC1
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000151 pronephros pronephros decreased length , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule morphology , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell mononucleate , abnormal
fast muscle cell circular , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000098871 GGA3 (1 of many) / si:ch73-157i16.3 / GGA3* / Q9NZ52* / Q8BMI3* / ADP-ribosylation factor-binding protein GGA3 * / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSDARG00000052928 arf6b / ADP-ribosylation factor 6b / ARF6* / P62330* / P62331* / ADP ribosylation factor 6*  / complex






 

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