Manteia

ENSG00000050820

Homo sapiens

Features

Gene ID:	ENSG00000050820

Biological name :	BCAR1

Synonyms :	BCAR1 / BCAR1, Cas family scaffolding protein / P56945

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	16
Strand:	-1
Band:	q23.1
Gene start:	75228187
Gene end:	75268053

Corresponding Affymetrix probe sets:	223116_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000458088 Ensembl peptide - ENSP00000457231 Ensembl peptide - ENSP00000457457 Ensembl peptide - ENSP00000162330 Ensembl peptide - ENSP00000377072 Ensembl peptide - ENSP00000377074 Ensembl peptide - ENSP00000391669 Ensembl peptide - ENSP00000392708 Ensembl peptide - ENSP00000440370 Ensembl peptide - ENSP00000440415 Ensembl peptide - ENSP00000442161 Ensembl peptide - ENSP00000443841 Ensembl peptide - ENSP00000454702 Ensembl peptide - ENSP00000455166 Ensembl peptide - ENSP00000455810 Ensembl peptide - ENSP00000456625 Ensembl peptide - ENSP00000456929 Ensembl peptide - ENSP00000457097 NCBI entrez gene - 9564 See in Manteia. OMIM - 602941 RefSeq - XM_017023899 RefSeq - NM_001170714 RefSeq - NM_001170715 RefSeq - NM_001170716 RefSeq - NM_001170717 RefSeq - NM_001170718 RefSeq - NM_001170719 RefSeq - NM_001170720 RefSeq - NM_001170721 RefSeq - NM_014567 RefSeq - XM_005256258 RefSeq - XM_005256259 RefSeq - XM_005256260 RefSeq - XM_011523475 RefSeq - XM_017023897 RefSeq - XM_017023898 RefSeq Peptide - NP_001164185 RefSeq Peptide - NP_001164186 RefSeq Peptide - NP_001164187 RefSeq Peptide - NP_001164188 RefSeq Peptide - NP_001164189 RefSeq Peptide - NP_001164190 RefSeq Peptide - NP_001164191 RefSeq Peptide - NP_001164192 RefSeq Peptide - NP_055382 swissprot - H3BVF0 swissprot - H3BTL5 swissprot - F5H855 swissprot - H3BN62 swissprot - H3BQJ7 swissprot - H3BSB2 swissprot - H3BSY4 swissprot - H3BTB0 swissprot - P56945 swissprot - H3BU42 Ensembl - ENSG00000050820

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
bcar1	ENSDARG00000056525	Danio rerio
BCAR1	ENSGALG00000042895	Gallus gallus
Bcar1	ENSMUSG00000031955	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
NEDD9 / Q14511 / neural precursor cell expressed, developmentally down-regulated 9	ENSG00000111859	37
EFS / O43281 / embryonal Fyn-associated substrate	ENSG00000100842	23
CASS4 / Q9NQ75 / Cas scaffolding protein family member 4	ENSG00000087589	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR001452	SH3 domain
IPR014928	Serine rich protein interaction domain
IPR021901	CAS family, C-terminal
IPR028848	Breast cancer anti-estrogen resistance protein 1
IPR035745	BCAR1, SH3 domain
IPR036028	SH3-like domain superfamily
IPR037362	CAS family

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001558	regulation of cell growth	TAS
biological_process	GO:0007015	actin filament organization	IDA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	ISS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	NAS
biological_process	GO:0007229	integrin-mediated signaling pathway	IDA
biological_process	GO:0008283	cell proliferation	TAS
biological_process	GO:0008286	insulin receptor signaling pathway	ISS
biological_process	GO:0010595	positive regulation of endothelial cell migration	IDA
biological_process	GO:0016477	cell migration	IDA
biological_process	GO:0030335	positive regulation of cell migration	IDA
biological_process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IMP
biological_process	GO:0042981	regulation of apoptotic process	TAS
biological_process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISS
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP
biological_process	GO:0048011	neurotrophin TRK receptor signaling pathway	ISS
biological_process	GO:0048012	hepatocyte growth factor receptor signaling pathway	IMP
biological_process	GO:0050851	antigen receptor-mediated signaling pathway	IDA
biological_process	GO:0050852	T cell receptor signaling pathway	NAS
biological_process	GO:0050853	B cell receptor signaling pathway	IDA
biological_process	GO:0051301	cell division	NAS
biological_process	GO:0060326	cell chemotaxis	IMP
cellular_component	GO:0001726	ruffle	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005925	focal adhesion	IDA
cellular_component	GO:0015629	actin cytoskeleton	IEA
cellular_component	GO:0030027	lamellipodium	IEA
cellular_component	GO:0030054	cell junction	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0017124	SH3 domain binding	IEA
molecular_function	GO:0019901	protein kinase binding	IPI

Pathways (from Reactome)

Pathway description

Downstream signal transduction

p130Cas linkage to MAPK signaling for integrins

VEGFA-VEGFR2 Pathway

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000080824	P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1	/ complex / reaction
ENSG00000101213	PTK6 / Q13882 / protein tyrosine kinase 6	/ complex / reaction
ENSG00000127314	RAP1B / P61224 / RAP1B, member of RAS oncogene family	/ complex / reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ complex / reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000110799	VWF / P04275 / von Willebrand factor	/ complex / reaction
ENSG00000005961	ITGA2B / P08514 / integrin subunit alpha 2b	/ complex / reaction
ENSG00000134853	P16234 / PDGFRA / platelet derived growth factor receptor alpha	/ complex / reaction
ENSG00000113721	P09619 / PDGFRB / platelet derived growth factor receptor beta	/ complex / reaction
ENSG00000062598	ELMO2 / Q96JJ3 / engulfment and cell motility 2	/ complex / reaction
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000171560	FGA / P02671 / fibrinogen alpha chain	/ complex / reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ complex / reaction
ENSG00000171564	FGB / P02675 / fibrinogen beta chain	/ complex / reaction
ENSG00000155849	ELMO1 / Q92556 / engulfment and cell motility 1	/ complex / reaction
ENSG00000115414	FN1 / P02751 / fibronectin 1	/ complex / reaction
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ complex / reaction
ENSG00000137076	TLN1 / Q9Y490 / talin 1	/ complex / reaction
ENSG00000171557	FGG / P02679 / fibrinogen gamma chain	/ complex / reaction
ENSG00000100311	PDGFB / P01127 / platelet derived growth factor subunit B	/ complex / reaction
ENSG00000116473	RAP1A / P62834 / RAP1A, member of RAS oncogene family	/ complex / reaction
ENSG00000197461	PDGFA / P04085 / platelet derived growth factor subunit A	/ complex / reaction
ENSG00000077420	Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein	/ complex / reaction
ENSG00000099942	CRKL / P46109 / CRK like proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000107338	SHB / Q15464 / SH2 domain containing adaptor protein B	/ complex / reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ complex / reaction
ENSG00000107263	Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1	/ complex / reaction

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr