ENSG00000155849


Homo sapiens

Features
Gene ID: ENSG00000155849
  
Biological name :ELMO1
  
Synonyms : ELMO1 / engulfment and cell motility 1 / Q92556
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p14.1
Gene start: 36854361
Gene end: 37449249
  
Corresponding Affymetrix probe sets: 204513_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396465
Ensembl peptide - ENSP00000395933
Ensembl peptide - ENSP00000397857
Ensembl peptide - ENSP00000416090
Ensembl peptide - ENSP00000413108
Ensembl peptide - ENSP00000406952
Ensembl peptide - ENSP00000406610
Ensembl peptide - ENSP00000312185
Ensembl peptide - ENSP00000379355
Ensembl peptide - ENSP00000379360
Ensembl peptide - ENSP00000391734
Ensembl peptide - ENSP00000394458
NCBI entrez gene - 9844     See in Manteia.
OMIM - 606420
RefSeq - XM_017012839
RefSeq - NM_001039459
RefSeq - NM_001206480
RefSeq - NM_001206482
RefSeq - NM_014800
RefSeq - NM_130442
RefSeq - XM_005249919
RefSeq - XM_006715805
RefSeq - XM_011515654
RefSeq - XM_017012838
RefSeq Peptide - NP_569709
RefSeq Peptide - NP_001034548
RefSeq Peptide - NP_001193409
RefSeq Peptide - NP_001193411
RefSeq Peptide - NP_055615
swissprot - C9JIW2
swissprot - C9JB20
swissprot - C9J5X3
swissprot - C9IZR8
swissprot - H7C0N5
swissprot - Q92556
swissprot - A4D1X5
swissprot - H7C0S6
swissprot - H7C3P3
Ensembl - ENSG00000155849
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elmo1ENSDARG00000098753Danio rerio
 si:dkey-56f14.7ENSDARG00000055400Danio rerio
 ELMO1ENSGALG00000035492Gallus gallus
 Elmo1ENSMUSG00000041112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELMO2 / Q96JJ3 / engulfment and cell motility 2ENSG0000006259875
ELMO3 / Q96BJ8 / engulfment and cell motility 3ENSG0000010289052


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006816  ELMO domain
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR024574  Domain of unknown function DUF3361
 IPR030715  Engulfment and cell motility protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment IGI
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016601 Rac protein signal transduction IGI
 biological_processGO:0030029 actin filament-based process IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048870 cell motility IGI
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IPI


Pathways (from Reactome)
Pathway description
Nef and signal transduction
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000134516 DOCK2 / Q92608 / dedicator of cytokinesis 2  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr