Manteia

ENSG00000080824

Homo sapiens

Features

Gene ID:	ENSG00000080824

Biological name :	HSP90AA1

Synonyms :	heat shock protein 90 alpha family class A member 1 / HSP90AA1 / P07900

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	-1
Band:	q32.31
Gene start:	102080738
Gene end:	102139699

Corresponding Affymetrix probe sets:	210211_s_at (Human Genome U133 Plus 2.0 Array) 211968_s_at (Human Genome U133 Plus 2.0 Array) 211969_at (Human Genome U133 Plus 2.0 Array) 214328_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000452241 Ensembl peptide - ENSP00000451400 Ensembl peptide - ENSP00000489370 Ensembl peptide - ENSP00000216281 Ensembl peptide - ENSP00000335153 Ensembl peptide - ENSP00000450712 NCBI entrez gene - 3320 See in Manteia. OMIM - 140571 RefSeq - XM_011536718 RefSeq - NM_001017963 RefSeq - NM_005348 RefSeq Peptide - NP_001017963 RefSeq Peptide - NP_005339 swissprot - P07900 swissprot - A0A0U1RR69 swissprot - G3V2J8 swissprot - H0YJF5 swissprot - G3V592 swissprot - K9JA46 Ensembl - ENSG00000080824

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
Q90474	ENSDARG00000010478	Danio rerio
HSP90AA1	ENSGALG00000033212	Gallus gallus
P07901	ENSMUSG00000021270	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1	ENSG00000096384	73
P14625 / HSP90B1 / heat shock protein 90 beta family member 1	ENSG00000166598	40
TRAP1 / Q12931 / TNF receptor associated protein 1	ENSG00000126602	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR001404	Heat shock protein Hsp90 family
IPR003594	Histidine kinase/HSP90-like ATPase
IPR019805	Heat shock protein Hsp90, conserved site
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR020575	Heat shock protein Hsp90, N-terminal
IPR036890	Histidine kinase/HSP90-like ATPase superfamily
IPR037196	HSP90, C-terminal domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000086	G2/M transition of mitotic cell cycle	TAS
biological_process	GO:0001934	positive regulation of protein phosphorylation	IDA
biological_process	GO:0006457	protein folding	IEA
biological_process	GO:0006839	mitochondrial transport	TAS
biological_process	GO:0006898	receptor-mediated endocytosis	TAS
biological_process	GO:0006950	response to stress	IEA
biological_process	GO:0006986	response to unfolded protein	NAS
biological_process	GO:0007004	telomere maintenance via telomerase	IDA
biological_process	GO:0007165	signal transduction	NAS
biological_process	GO:0009408	response to heat	ISS
biological_process	GO:0009409	response to cold	ISS
biological_process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0021955	central nervous system neuron axonogenesis	IEA
biological_process	GO:0030010	establishment of cell polarity	IEA
biological_process	GO:0031396	regulation of protein ubiquitination	IDA
biological_process	GO:0032273	positive regulation of protein polymerization	IDA
biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0038128	ERBB2 signaling pathway	TAS
biological_process	GO:0042026	protein refolding	TAS
biological_process	GO:0043254	regulation of protein complex assembly	NAS
biological_process	GO:0043312	neutrophil degranulation	TAS
biological_process	GO:0043335	protein unfolding	NAS
biological_process	GO:0045040	protein import into mitochondrial outer membrane	IDA
biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IEA
biological_process	GO:0046677	response to antibiotic	ISS
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0048675	axon extension	IEA
biological_process	GO:0050821	protein stabilization	TAS
biological_process	GO:0050999	regulation of nitric-oxide synthase activity	TAS
biological_process	GO:0051131	chaperone-mediated protein complex assembly	IDA
biological_process	GO:0051186	cofactor metabolic process	TAS
biological_process	GO:0051897	positive regulation of protein kinase B signaling	IEA
biological_process	GO:0051973	positive regulation of telomerase activity	IDA
biological_process	GO:0061684	chaperone-mediated autophagy	TAS
biological_process	GO:0097711	ciliary basal body-plasma membrane docking	TAS
biological_process	GO:1900034	regulation of cellular response to heat	TAS
biological_process	GO:1902949	positive regulation of tau-protein kinase activity	IDA
biological_process	GO:1903364	positive regulation of cellular protein catabolic process	IGI
biological_process	GO:1905323	telomerase holoenzyme complex assembly	IDA
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0032587	ruffle membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IDA
cellular_component	GO:0034774	secretory granule lumen	TAS
cellular_component	GO:0042470	melanosome	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043202	lysosomal lumen	TAS
cellular_component	GO:0043209	myelin sheath	IEA
cellular_component	GO:0044294	dendritic growth cone	IEA
cellular_component	GO:0044295	axonal growth cone	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0071682	endocytic vesicle lumen	TAS
cellular_component	GO:1904813	ficolin-1-rich granule lumen	TAS
molecular_function	GO:0000166	nucleotide binding	TAS
molecular_function	GO:0003723	RNA binding	HDA
molecular_function	GO:0004713	protein tyrosine kinase activity	EXP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016887	ATPase activity	IDA
molecular_function	GO:0023026	MHC class II protein complex binding	HDA
molecular_function	GO:0030235	nitric-oxide synthase regulator activity	IEA
molecular_function	GO:0030911	TPR domain binding	TAS
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0042826	histone deacetylase binding	IPI
molecular_function	GO:0048156	tau protein binding	IPI
molecular_function	GO:0051020	GTPase binding	IPI
molecular_function	GO:0051082	unfolded protein binding	IEA
molecular_function	GO:0070182	DNA polymerase binding	IPI
molecular_function	GO:0097110	scaffold protein binding	IPI
molecular_function	GO:0097718	disordered domain specific binding	IPI
molecular_function	GO:1990782	protein tyrosine kinase binding	IPI

Pathways (from Reactome)

Pathway description

Signaling by ERBB2

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

vRNP Assembly

Regulation of actin dynamics for phagocytic cup formation

eNOS activation

Regulation of PLK1 Activity at G2/M Transition

Scavenging by Class F Receptors

HSP90 chaperone cycle for steroid hormone receptors (SHR)

HSF1 activation

Attenuation phase

HSF1-dependent transactivation

Loss of Nlp from mitotic centrosomes

Recruitment of mitotic centrosome proteins and complexes

Loss of proteins required for interphase microtubule organization from the centrosome

Recruitment of NuMA to mitotic centrosomes

Sema3A PAK dependent Axon repulsion

VEGFA-VEGFR2 Pathway

VEGFR2 mediated vascular permeability

Uptake and function of diphtheria toxin

PIWI-interacting RNA (piRNA) biogenesis

Anchoring of the basal body to the plasma membrane

Constitutive Signaling by EGFRvIII

Interleukin-4 and Interleukin-13 signaling

Neutrophil degranulation

The role of GTSE1 in G2/M progression after G2 checkpoint

AURKA Activation by TPX2

Downregulation of ERBB2 signaling

ESR-mediated signaling

Estrogen-dependent gene expression

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000004478	FKBP4 / Q02790 / FK506 binding protein 4	/ complex / reaction
ENSG00000050820	BCAR1 / P56945 / BCAR1, Cas family scaffolding protein	/ complex / reaction
ENSG00000080824	P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1	/ complex / reaction
ENSG00000091831	ESR1 / P03372 / estrogen receptor 1	/ complex
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000113070	HBEGF / Q99075 / heparin binding EGF like growth factor	/ reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ complex / reaction
ENSG00000124882	EREG / O14944 / epiregulin	/ reaction
ENSG00000113580	NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1	/ complex
ENSG00000077800	FKBP6 / O75344 / FK506 binding protein 6	/ complex
ENSG00000082175	PGR / P06401 / progesterone receptor	/ complex
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000110958	PTGES3 / Q15185 / prostaglandin E synthase 3	/ complex / reaction
ENSG00000178568	ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	/ reaction
ENSG00000138798	EGF / P01133 / epidermal growth factor	/ complex / reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ reaction
ENSG00000110395	CBL / P22681 / Cbl proto-oncogene	/ complex / reaction
ENSG00000062598	ELMO2 / Q96JJ3 / engulfment and cell motility 2	/ complex / reaction
ENSG00000158458	NRG2 / O14511 / neuregulin 2	/ reaction
ENSG00000164867	NOS3 / P29474 / nitric oxide synthase 3	/ reaction / complex
ENSG00000146648	EGFR / P00533 / epidermal growth factor receptor	/ complex / reaction
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000157168	NRG1 / Q02297 / neuregulin 1	/ reaction
ENSG00000065361	ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3	/ reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ complex / reaction
ENSG00000140009	ESR2 / Q92731 / estrogen receptor 2	/ complex
ENSG00000155849	ELMO1 / Q92556 / engulfment and cell motility 1	/ complex / reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000105974	CAV1 / Q03135 / caveolin 1	/ reaction / complex
ENSG00000151623	NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2	/ complex
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ complex / reaction
ENSG00000142208	AKT1 / P31749 / AKT serine/threonine kinase 1	/ complex / reaction
ENSG00000198668	CALM1 / P0DP23 / calmodulin 1	/ reaction / complex
ENSG00000096060	FKBP5 / Q13451 / FK506 binding protein 5	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction
ENSG00000169083	AR / P10275 / androgen receptor	/ complex
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction
ENSG00000107338	SHB / Q15464 / SH2 domain containing adaptor protein B	/ complex / reaction
ENSG00000174808	BTC / P35070 / betacellulin	/ reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000169752	NRG4 / Q8WWG1 / neuregulin 4	/ reaction
ENSG00000185122	HSF1 / Q00613 / heat shock transcription factor 1	/ complex / reaction
ENSG00000105401	CDC37 / Q16543 / cell division cycle 37	/ complex / reaction
ENSG00000109971	HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8	/ complex / reaction
ENSG00000089159	PXN / P49023 / paxillin	/ complex / reaction
ENSG00000124762	CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A	/ complex / reaction
ENSG00000109458	GAB1 / Q13480 / GRB2 associated binding protein 1	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000138448	ITGAV / P06756 / integrin subunit alpha V	/ reaction
ENSG00000067560	RHOA / P61586 / ras homolog family member A	/ reaction
ENSG00000134318	ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2	/ reaction
ENSG00000112851	ERBIN / Q96RT1 / erbb2 interacting protein	/ complex / reaction
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ complex / reaction
ENSG00000168439	STIP1 / P31948 / stress induced phosphoprotein 1	/ complex / reaction
ENSG00000171497	PPID / Q08752 / peptidylprolyl isomerase D	/ complex
ENSG00000069345	DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2	/ reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000086061	DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1	/ reaction
ENSG00000106683	LIMK1 / P53667 / LIM domain kinase 1	/ complex / reaction
ENSG00000140403	DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4	/ reaction
ENSG00000096384	P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1	/ complex
ENSG00000120899	PTK2B / Q14289 / protein tyrosine kinase 2 beta	/ reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000204315	FKBPL / Q9UIM3 / FK506 binding protein like	/ complex / reaction
ENSG00000204389	HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A	/ complex / reaction
ENSG00000204388	HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B	/ complex / reaction
ENSG00000067900	ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1	/ reaction
ENSG00000075218	GTSE1 / Q9NYZ3 / G2 and S-phase expressed 1	/ complex / reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr