ENSG00000204388


Homo sapiens

Features
Gene ID: ENSG00000204388
  
Biological name :HSPA1B
  
Synonyms : heat shock protein family A (Hsp70) member 1B / HSPA1B / P0DMV9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.33
Gene start: 31827735
Gene end: 31830255
  
Corresponding Affymetrix probe sets: 200800_s_at (Human Genome U133 Plus 2.0 Array)   202581_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364801
NCBI entrez gene - 3304     See in Manteia.
OMIM - 603012
RefSeq - NM_005346
RefSeq Peptide - NP_005337
swissprot - A8K5I0
swissprot - P0DMV9
Ensembl - ENSG00000204388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Hspa1aENSMUSG00000091971Mus musculus
 Hspa1bENSMUSG00000090877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1AENSG00000204389100
HSPA1L / P34931 / heat shock protein family A (Hsp70) member 1 likeENSG0000020439089
HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8ENSG0000010997186
HSPA2 / P54652 / heat shock protein family A (Hsp70) member 2ENSG0000012680384
HSPA6 / P17066 / heat shock protein family A (Hsp70) member 6ENSG0000017311082
HSPA5 / P11021 / heat shock protein family A (Hsp70) member 5ENSG0000004457462
HSPA14 / Q0VDF9 / heat shock protein family A (Hsp70) member 14ENSG0000018752227
HSPA14 / heat shock protein family A (Hsp70) member 14ENSG000002840247


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0042026 protein refolding IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0046034 ATP metabolic process IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050821 protein stabilization TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0070370 cellular heat acclimation IMP
 biological_processGO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0090063 positive regulation of microtubule nucleation IMP
 biological_processGO:0090084 negative regulation of inclusion body assembly IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016234 inclusion body IDA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042623 ATPase activity, coupled TAS
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044183 protein binding involved in protein folding IDA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051082 unfolded protein binding NAS
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / reaction / complex
 ENSG00000105821 DNAJC2 / Q99543 / DnaJ heat shock protein family (Hsp40) member C2  / reaction
 ENSG00000105993 DNAJB6 / O75190 / DnaJ heat shock protein family (Hsp40) member B6  / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000149196 Q53FT3 / HIKESHI / Hikeshi, heat shock protein nuclear import factor  / complex / reaction
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / complex / reaction
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / complex / reaction
 ENSG00000168259 DNAJC7 / Q99615 / DnaJ heat shock protein family (Hsp40) member C7  / reaction
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / complex / reaction
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / complex / reaction
 ENSG00000120694 HSPH1 / Q92598 / heat shock protein family H (Hsp110) member 1  / reaction
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction






 

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