ENSDARG00000044968


Danio rerio

Features
Gene ID: ENSDARG00000044968
  
Biological name :vcla
  
Synonyms : vcla / vinculin a
  
Possible biological names infered from orthology : P18206 / Q64727 / VCL / vinculin
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 25211939
Gene end: 25284716
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000039827
Ensembl peptide - ENSDARP00000105799
NCBI entrez gene - 552980     See in Manteia.
swissprot - B3DI32
swissprot - B8JIH2
ZFIN ID - ZDB-GENE-050506-61
Ensembl - ENSDARG00000044968
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VCLENSGALG00000005079Gallus gallus
 VCLENSG00000035403Homo sapiens
 VclENSMUSG00000021823Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vcla / vinculin a / VCL* / P18206* / vinculin*ENSDARG0000009869575
B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...ENSDARG0000002478518
ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*ENSDARG0000010244118
ctnnal1 / catenin (cadherin-associated protein), alpha-like 1 / O88327* / Q9UBT7* / Alpha-catulin * / catenin alpha like 1*ENSDARG000000181629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR006077  Vinculin/alpha-catenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IMP
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Smooth Muscle Contraction
MAP2K and MAPK activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex






 

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