ENSDARG00000062328


Danio rerio

Features
Gene ID: ENSDARG00000062328
  
Biological name :rasgrp2
  
Synonyms : rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated)
  
Possible biological names infered from orthology : Q7LDG7 / Q9QUG9 / RAS guanyl releasing protein 2
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 28415888
Gene end: 28439596
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000084413
Ensembl peptide - ENSDARP00000113446
swissprot - E9QJM1
swissprot - F1R763
ZFIN ID - ZDB-GENE-091118-124
Ensembl - ENSDARG00000062328
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7LDG7ENSG00000068831Homo sapiens
 Q9QUG9ENSMUSG00000032946Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASGRP2 / RAS guanyl releasing protein 2 / Q7LDG7*ENSDARG0000009909261
rasgrp3 / RAS guanyl releasing protein 3 (calcium and DAG-regulated) / Q8IV61* / RAS guanyl releasing protein 3*ENSDARG0000007786448
rasgrp4 / RAS guanyl releasing protein 4 / Q8BTM9* / Q8TDF6*ENSDARG0000006179640
rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSDARG0000001094516
rapgef2 / Rap guanine nucleotide exchange factor (GEF) 2 / Q8CHG7* / Q9Y4G8* / Rap guanine nucleotide exchange factor 2*ENSDARG0000000548215
si:dkey-253i9.4ENSDARG0000006145914
Q6DHR3 / rasgef1ba / RasGEF domain family, member 1Ba / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG0000003361413
rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3 / Q8VCC8* / O95398* / Rap guanine nucleotide exchange factor 3* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapge...ENSDARG0000007929113
rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor 4*ENSDARG0000007987213
Q6DBW1 / rasgef1bb / RasGEF domain family, member 1Bb / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG0000004425112
rapgefl1 / Rap guanine nucleotide exchange factor (GEF)-like 1 / Q68EF8* / Q9UHV5* / Rap guanine nucleotide exchange factor like 1*ENSDARG0000007991212
rapgef5a / Rap guanine nucleotide exchange factor (GEF) 5a / Q92565* / RAPGEF5* / Rap guanine nucleotide exchange factor 5*ENSDARG0000007527111
zgc:171558 / Q8WZA2* / Q9EQZ6* / RAPGEF4* / Rap guanine nucleotide exchange factor 4* / Rap guanine nucleotide exchange factor (GEF) 4*ENSDARG0000007592411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr