ENSDARG00000026294


Danio rerio

Features
Gene ID: ENSDARG00000026294
  
Biological name :erbb2
  
Synonyms : erbb2 / erb-b2 receptor tyrosine kinase 2
  
Possible biological names infered from orthology : P04626 / P70424 / Receptor tyrosine-protein kinase erbB-2
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 9360316
Gene end: 9438227
  
Corresponding Affymetrix probe sets: Dr.22611.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000010252
NCBI entrez gene - 386966     See in Manteia.
RefSeq - NM_200119
RefSeq Peptide - NP_956413
swissprot - F1R5S1
ZFIN ID - ZDB-GENE-031118-121
Ensembl - ENSDARG00000026294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERBB2ENSGALG00000031529Gallus gallus
 ERBB2ENSG00000141736Homo sapiens
 Erbb2ENSMUSG00000062312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch73-383l1.1ENSDARG0000009040845
erbb4a / erb-b2 receptor tyrosine kinase 4aENSDARG0000006320744
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000003699337
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000000620235
erbb4b / erb-b2 receptor tyrosine kinase 4bENSDARG0000008953634
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...ENSDARG0000001384723
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSDARG0000005690923
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000000467215
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000003957714
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000002284113
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000010045613
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000010440913
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*ENSDARG0000000818612
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000009064612
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*ENSDARG0000001575211
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *ENSDARG0000006943311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0032285 non-myelinated axon ensheathment IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0048914 myelination of anterior lateral line nerve axons IMP
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0048932 myelination of posterior lateral line nerve axons IMP
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0060973 cell migration involved in heart development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased contractility , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve mislocalised , abnormal
posterior lateral line nerve defasciculated , abnormal
posterior lateral line nerve axon decreased amount , abnormal
posterior lateral line nerve myelin sheath absent , abnormal
posterior lateral line nerve sodium channel complex decreased amount , abnormal
posterior lateral line nerve sodium channel complex asymmetrical , abnormal
posterior lateral line nerve sodium channel complex elongated , abnormal
posterior lateral line nerve sodium channel complex undistributed , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion neuron absent , abnormal
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 ZFA:0000243 neuromast neuromast increased amount , abnormal
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 ZFA:0000471 atrium atrium decreased contractility , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line myelination in peripheral nervous system arrested , abnormal
posterior lateral line lacks all parts of type myelinating Schwann cell , abnormal
posterior lateral line myelinating Schwann cell absent , abnormal
posterior lateral line axon regeneration decreased process quality , abnormal
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 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion regeneration decreased process quality , abnormal
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 ZFA:0001319 myocardium myocardium lacks all parts of type trabecular layer , abnormal
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 ZFA:0001576 sympathetic nervous system sympathetic nervous system neuron absent , abnormal
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 ZFA:0005062 compact layer of ventricle compact layer of ventricle apical region has fewer parts of type compact layer of ventricle cardiac myofibril, abnormal
compact layer of ventricle basal cortex has extra parts of type compact layer of ventricle cardiac myofibril, abnormal
compact layer of ventricle ventricular cardiac myofibril assembly decreased process quality , abnormal
compact layer of ventricle cardiac myofibril increased diameter , abnormal
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 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell absent , abnormal
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 ZFA:0009183 epidermal cell epidermal cell morphology , abnormal
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 ZFA:0009238 afferent neuron afferent neuron defasciculated , abnormal
afferent neuron axon lacks all parts of type myelinating Schwann cell , abnormal
afferent neuron axon regeneration decreased process quality , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
cardiac muscle cell has fewer parts of type cardiac muscle cell cell projection, abnormal
cardiac muscle cell cell projection transient , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction / complex
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / complex
 ENSDARG00000018328 rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000021309 rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / complex / reaction
 ENSDARG00000074670 matk / megakaryocyte-associated tyrosine kinase / P42679*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSDARG00000030532 arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000100913 arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...  / complex / reaction






 

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