ENSDARG00000100456


Danio rerio

Features
Gene ID: ENSDARG00000100456
  
Biological name :ptk2aa
  
Synonyms : protein tyrosine kinase 2aa / ptk2aa
  
Possible biological names infered from orthology : P34152 / protein tyrosine kinase 2 / PTK2 / PTK2 protein tyrosine kinase 2 / Q05397
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 1790797
Gene end: 1848480
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131584
Ensembl peptide - ENSDARP00000132707
Ensembl peptide - ENSDARP00000137309
swissprot - A0A0R4ICT0
swissprot - A0A0R4IEL2
swissprot - A0A0R4IRT2
ZFIN ID - ZDB-GENE-031114-5
Ensembl - ENSDARG00000100456
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTK2ENSGALG00000031741Gallus gallus
 PTK2ENSG00000169398Homo sapiens
 Ptk2ENSMUSG00000022607Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000000467265
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000002284135
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000003957735
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000003699317
erbb4a / erb-b2 receptor tyrosine kinase 4aENSDARG0000006320717
si:ch73-383l1.1ENSDARG0000009040817
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *ENSDARG0000002629416
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000000620215
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000009064613
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000010440913
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*ENSDARG0000000818612
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*ENSDARG0000001575211
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *ENSDARG0000006943311
erbb4b / erb-b2 receptor tyrosine kinase 4bENSDARG0000008953610
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...ENSDARG000000138475
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSDARG000000569095


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007172 signal complex assembly IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart decreased functionality , abnormal
heart focal adhesion absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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