ENSGALG00000042259


Gallus gallus

Features
Gene ID: ENSGALG00000042259
  
Biological name :DOCK1
  
Synonyms : dedicator of cytokinesis 1 / DOCK1
  
Possible biological names infered from orthology : Dedicator of cytokinesis protein 1 / Q14185 / Q8BUR4
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 32938446
Gene end: 33212336
  
Corresponding Affymetrix probe sets: GgaAffx.505.1.S1_at (Chicken Array)   GgaAffx.6137.1.S1_at (Chicken Array)   GgaAffx.8787.1.S1_at (Chicken Array)   GgaAffx.8912.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044707
NCBI entrez gene - 423960     See in Manteia.
RefSeq - XM_004942353
RefSeq - XM_421819
RefSeq - XM_015289051
RefSeq - XM_015289052
swissprot - A0A1D5NWG7
Ensembl - ENSGALG00000042259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock1ENSDARG00000099093Danio rerio
 DOCK1ENSG00000150760Homo sapiens
 Dock1ENSMUSG00000058325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK5* / B2RY04* / Q9H7D0* / dedicator of cytokinesis 5* / Dedicator of cytokinesis protein 5 *ENSGALG0000000031165
DOCK2 / dedicator of cytokinesis 2 / Q8C3J5* / Q92608* / Dedicator of cytokinesis protein 2 *ENSGALG0000000208058
DOCK3 / dedicator of cytokinesis 3 / Q8IZD9*ENSGALG0000000233537
DOCK4 / dedicator of cytokinesis 4 / P59764* / Q8N1I0* / Dedicator of cytokinesis protein 4 *ENSGALG0000000948023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR030717  Dedicator of cytokinesis protein 1
 IPR032376  Dedicator of cytokinesis, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction






 

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