ENSGALG00000007130


Gallus gallus

Features
Gene ID: ENSGALG00000007130
  
Biological name :RAC1
  
Synonyms : RAC1 / Rac family small GTPase 1
  
Possible biological names infered from orthology : P63000 / P63001 / RAS-related C3 botulinum substrate 1
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 8858754
Gene end: 8872514
  
Corresponding Affymetrix probe sets: Gga.1109.1.S1_at (Chicken Array)   Gga.1109.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011538
NCBI entrez gene - 395871     See in Manteia.
RefSeq - NM_205017
RefSeq - XM_015294138
RefSeq Peptide - NP_990348
swissprot - Q6LC82
Ensembl - ENSGALG00000007130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac1aENSDARG00000074849Danio rerio
 rac1bENSDARG00000087954Danio rerio
 rac1lENSDARG00000054649Danio rerio
 rac1lENSDARG00000096549Danio rerio
 si:ch211-1f22.1ENSDARG00000013203Danio rerio
 si:ch211-1f22.2ENSDARG00000096666Danio rerio
 RAC1ENSG00000136238Homo sapiens
 Rac1ENSMUSG00000001847Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAC3 / Rac family small GTPase 3 / P60763* / P60764* / RAS-related C3 botulinum substrate 3*ENSGALG0000004060694
RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *ENSGALG0000001245692
RHOGLENSGALG0000000547572
CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *ENSGALG0000000479670
RHOG / ras homolog family member G / P84095* / P84096*ENSGALG0000002699570
RHOQ / rho-related GTP-binding protein RhoQ / P17081* / Q8R527* / ras homolog family member Q*ENSGALG0000001001064
RHOJ / rho-related GTP-binding protein RhoJ / Q9ER71* / Q9H4E5* / ras homolog family member J*ENSGALG0000001185560
RHOU* / Q7L0Q8* / Q9EQT3* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSGALG0000002573857
RHOV / ras homolog family member V / Q8VDU1* / Q96L33* / Rho-related GTP-binding protein RhoV *ENSGALG0000002804754
RHOBTB1 / Rho related BTB domain containing 1 / O94844* / Q9DAK3* / Rho-related BTB domain-containing protein 1 *ENSGALG0000000307345
RHOBTB2 / Rho related BTB domain containing 2 / Q91V93* / Q9BYZ6* / Rho-related BTB domain-containing protein 2 *ENSGALG0000003402044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0032707 negative regulation of interleukin-23 production IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051668 localization within membrane IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060263 regulation of respiratory burst IEA
 biological_processGO:0060297 regulation of sarcomere organization IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:0097178 ruffle assembly IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
NTRK2 activates RAC1
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSGALG00000008669 CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000000816 SRGAP2* / O75044* / P0DJJ0* / P0DMP2* / Q91Z67* / SRGAP2C* / SRGAP2B* / SLIT-ROBO Rho GTPase activating protein 2* / SLIT-ROBO Rho GTPase activating protein 2B* / SLIT-ROBO Rho GTPase activ...  / complex / reaction
 ENSGALG00000001264 PLXNA2 / plexin A2 / O75051* / P70207*  / complex
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / complex / reaction
 ENSGALG00000004700 NCF2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000006109 MAPK8 / mitogen-activated protein kinase 8 / P45983* / Q91Y86*  / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / reaction / complex
 ENSGALG00000005572 NOXO1 / NADPH oxidase organizer 1 / Q8NFA2* / Q8VCM2*  / complex / reaction
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / complex / reaction
 ENSGALG00000008952 NOXA1 / NADPH oxidase activator 1 / Q86UR1* / Q8CJ00*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000009621 ACTB / P60706 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60709* / P60710* / actin beta*  / complex / reaction
 ENSGALG00000006097 PLXNA1 / plexin A1 / P70206* / Q9UIW2*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000016261 CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *  / complex / reaction
 ENSGALG00000042538 BAIAP2 / BAI1 associated protein 2 / Q8BKX1* / Q9UQB8* / Brain-specific angiosis inhibitor 1-associated protein 2 *  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction / complex
 ENSGALG00000023703 GIT1 / GIT ArfGAP 1 / Q68FF6* / Q9Y2X7* / ARF GTPase-activating protein GIT1 *  / reaction / complex
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000029367 CYBA / cytochrome b-245 alpha chain / P13498* / Q61462* / Cytochrome b-245 light chain *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000006017 DOCK11 / dedicator of cytokinesis 11 / A2AF47* / Q5JSL3* / Dedicator of cytokinesis protein 11 *  / complex / reaction
 ENSGALG00000016883 DOCK9 / dedicator of cytokinesis 9 / Q9BZ29* / dedicator of cytokinesis protein 9 isoform 5 *  / complex / reaction
 ENSGALG00000014978 IQGAP2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex / reaction
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / reaction
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / reaction
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / reaction
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / reaction
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / reaction
 ENSGALG00000030162 IQGAP1 / IQ motif containing GTPase activating protein 1 / P46940* / Q9JKF1* / Ras GTPase-activating-like protein IQGAP1 *  / complex / reaction
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / complex / reaction






 

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