ENSGALG00000004796


Gallus gallus

Features
Gene ID: ENSGALG00000004796
  
Biological name :CDC42
  
Synonyms : CDC42 / Cell division control protein 42 homolog / Q90694
  
Possible biological names infered from orthology : Cell division control / cell division cycle 42 / P60766 / P60953
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 6358184
Gene end: 6379434
  
Corresponding Affymetrix probe sets: Gga.4438.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050376
Ensembl peptide - ENSGALP00000062153
Ensembl peptide - ENSGALP00000050674
Ensembl peptide - ENSGALP00000034254
NCBI entrez gene - 395917     See in Manteia.
RefSeq - XM_015296825
RefSeq - XM_015296826
RefSeq - XM_015296827
RefSeq - NM_205048
RefSeq Peptide - NP_990379
swissprot - Q90694
swissprot - A0A1D5PD33
swissprot - A0A1L1RTL5
Ensembl - ENSGALG00000004796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc42ENSDARG00000044573Danio rerio
 CDC42ENSG00000070831Homo sapiens
 Cdc42ENSMUSG00000006699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*ENSGALG0000000713071
RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *ENSGALG0000001245669
RAC3 / Rac family small GTPase 3 / P60763* / P60764* / RAS-related C3 botulinum substrate 3*ENSGALG0000004060669
RHOQ / rho-related GTP-binding protein RhoQ / P17081* / Q8R527* / ras homolog family member Q*ENSGALG0000001001066
RHOJ / rho-related GTP-binding protein RhoJ / Q9ER71* / Q9H4E5* / ras homolog family member J*ENSGALG0000001185563
RHOGLENSGALG0000000547562
RHOG / ras homolog family member G / P84095* / P84096*ENSGALG0000002699561
RHOU* / Q7L0Q8* / Q9EQT3* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSGALG0000002573858
RHOV / ras homolog family member V / Q8VDU1* / Q96L33* / Rho-related GTP-binding protein RhoV *ENSGALG0000002804755
RHOBTB1 / Rho related BTB domain containing 1 / O94844* / Q9DAK3* / Rho-related BTB domain-containing protein 1 *ENSGALG0000000307340
RHOBTB2 / Rho related BTB domain containing 2 / Q91V93* / Q9BYZ6* / Rho-related BTB domain-containing protein 2 *ENSGALG0000003402040


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003161 cardiac conduction system development IEA
 biological_processGO:0003334 keratinocyte development IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0007097 nuclear migration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0031274 positive regulation of pseudopodium assembly ISS
 biological_processGO:0031333 negative regulation of protein complex assembly ISS
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032467 positive regulation of cytokinesis ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034329 cell junction assembly ISS
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035088 establishment or maintenance of apical/basal cell polarity IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0036336 dendritic cell migration IEA
 biological_processGO:0038189 neuropilin signaling pathway IEA
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045185 maintenance of protein location ISS
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity ISS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0048664 neuron fate determination IEA
 biological_processGO:0048730 epidermis morphogenesis IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0051489 regulation of filopodium assembly ISS
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051647 nucleus localization IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore ISS
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IEA
 biological_processGO:0060789 hair follicle placode formation IEA
 biological_processGO:0060997 dendritic spine morphogenesis ISS
 biological_processGO:0071338 positive regulation of hair follicle cell proliferation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0000322 storage vacuole IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017119 Golgi transport complex IEA
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0030496 midbody ISS
 cellular_componentGO:0031256 leading edge membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042995 cell projection ISS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0051233 spindle midzone ISS
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0072686 mitotic spindle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0032427 GBD domain binding IEA
 molecular_functionGO:0034191 apolipoprotein A-I receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051022 Rho GDP-dissociation inhibitor binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
EGFR downregulation
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex
 ENSGALG00000008669 CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *  / reaction
 ENSGALG00000005713 NCKIPSD / NCK interacting protein with SH3 domain / Q9ESJ4* / Q9NZQ3*  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000006017 DOCK11 / dedicator of cytokinesis 11 / A2AF47* / Q5JSL3* / Dedicator of cytokinesis protein 11 *  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000009621 ACTB / P60706 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60709* / P60710* / actin beta*  / complex / reaction
 ENSGALG00000016883 DOCK9 / dedicator of cytokinesis 9 / Q9BZ29* / dedicator of cytokinesis protein 9 isoform 5 *  / complex / reaction
 ENSGALG00000014978 IQGAP2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000015152 BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex
 ENSGALG00000011170 WIPF3 / WAS/WASL interacting protein family member 3 / A6NGB9*  / reaction
 ENSGALG00000015132 CDH2 / P10288 / Cadherin-2 / P15116* / P19022*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000012525 FMNL2 / formin like 2 / A2APV2* / Q96PY5* / Formin-like protein 2 *  / complex / reaction
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / reaction
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000030040 CDH15 / cadherin 15 / P33146* / P55291*  / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSGALG00000030162 IQGAP1 / IQ motif containing GTPase activating protein 1 / P46940* / Q9JKF1* / Ras GTPase-activating-like protein IQGAP1 *  / complex / reaction
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / complex / reaction
 ENSGALG00000036441 WIPF1 / WAS/WASL interacting protein family member 1 / O43516* / Q8K1I7*  / reaction
 ENSGALG00000035419 CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex






 

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