ENSGALG00000002447


Gallus gallus

Features
Gene ID: ENSGALG00000002447
  
Biological name :CTNNA1
  
Synonyms : catenin alpha 1 / CTNNA1
  
Possible biological names infered from orthology : P26231 / P35221
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 2590011
Gene end: 2698188
  
Corresponding Affymetrix probe sets: Gga.11015.1.S1_at (Chicken Array)   Gga.4722.1.S1_s_at (Chicken Array)   GgaAffx.25492.1.S1_at (Chicken Array)   GgaAffx.25492.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003847
Ensembl peptide - ENSGALP00000048815
NCBI entrez gene - 416184     See in Manteia.
RefSeq - XM_414513
swissprot - A0A1D5P7X0
swissprot - E1C7M7
Ensembl - ENSGALG00000002447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctnna1ENSDARG00000102441Danio rerio
 CTNNA1ENSG00000044115Homo sapiens
 Ctnna1ENSMUSG00000037815Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTNNA3 / catenin alpha 3 / Q65CL1* / Q9UI47*ENSGALG0000000284560
CTNNA2 / catenin alpha-2 / P26232* / Q61301* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA.*ENSGALG0000002785352
CTNNA2* / P26232* / Q61301* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA.*ENSGALG0000001596630
VCL / P12003 / Vinculin / P18206* / Q64727*ENSGALG0000000507924
CTNNAL1 / catenin alpha like 1 / O88327* / Q9UBT7* / Alpha-catulin *ENSGALG0000001320722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR001033  Alpha-catenin
 IPR006077  Vinculin/alpha-catenin
 IPR030047  Alpha E-catenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IEA
 biological_processGO:0007406 negative regulation of neuroblast proliferation IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0071681 cellular response to indole-3-methanol IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2001045 negative regulation of integrin-mediated signaling pathway IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005915 zonula adherens IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
Adherens junctions interactions
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000000608 CDH1 / cadherin 1 / P12830*  / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / complex
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000017414 JUP / junction plakoglobin / P14923* / Q02257*  / complex / reaction
 ENSGALG00000015152 BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*  / complex / reaction
 ENSGALG00000015132 CDH2 / P10288 / Cadherin-2 / P15116* / P19022*  / complex
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex
 ENSGALG00000032349 CDH5 / Q8AYD0 / Cadherin-5 / P33151* / P55284*  / complex
 ENSGALG00000030040 CDH15 / cadherin 15 / P33146* / P55291*  / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSGALG00000035419 CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex / reaction






 

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