ENSGALG00000014786


Gallus gallus

Features
Gene ID: ENSGALG00000014786
  
Biological name :PIK3R1
  
Synonyms : phosphoinositide-3-kinase regulatory subunit 1 / PIK3R1
  
Possible biological names infered from orthology : P26450 / P27986
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 21646751
Gene end: 21656155
  
Corresponding Affymetrix probe sets: Gga.18018.1.S1_s_at (Chicken Array)   GgaAffx.24529.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023822
Ensembl peptide - ENSGALP00000056611
NCBI entrez gene - 427171     See in Manteia.
RefSeq - XM_004937313
RefSeq - XM_004937312
swissprot - E1C8M4
swissprot - A0A1D5PUK7
Ensembl - ENSGALG00000014786
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r1ENSDARG00000038524Danio rerio
 P27986ENSG00000145675Homo sapiens
 P26450ENSMUSG00000041417Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64143* / PIK3R3* / Q92569* / AL358075.4* / AL670603.1* / phosphoinositide-3-kinase regulatory subunit 3* / Phosphatidylinositol 3-kinase regulatory subunit gamma *ENSGALG0000001033574
O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *ENSGALG0000000342873


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001720  PI3K p85/p55 subunit
 IPR032498  PI3K p85 subunit, inter-SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IBA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0060396 growth hormone receptor signaling pathway IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:1990578 perinuclear endoplasmic reticulum membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA
 molecular_functionGO:0043125 ErbB-3 class receptor binding IEA
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / complex / reaction
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000008669 CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000021529 GP1BB / glycoprotein Ib platelet beta subunit / P13224* / P56400* / glycoprotein Ib, beta polypeptide*  / complex / reaction
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / complex / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / complex / reaction
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / complex / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000005547 Q9DDT2 / PIK3AP1 / Phosphoinositide 3-kinase adapter protein 1 / Q6ZUJ8* / Q9EQ32* / phosphoinositide-3-kinase adaptor protein 1*  / complex
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / complex / reaction
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000026995 RHOG / ras homolog family member G / P84095* / P84096*  / complex / reaction
 ENSGALG00000023781 TREM2 / triggering receptor expressed on myeloid cells 2 / Q99NH8* / Q9NZC2*  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000012456 RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / reaction / complex
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / complex
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000045125 GP5 / glycoprotein V platelet / P40197*  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / complex / reaction
 ENSGALG00000031387 YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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