ENSGALG00000029983


Gallus gallus

Features
Gene ID: ENSGALG00000029983
  
Biological name :ANGPT1
  
Synonyms : angiopoietin 1 / ANGPT1
  
Possible biological names infered from orthology : O08538 / Q15389
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 131784819
Gene end: 131949415
  
Corresponding Affymetrix probe sets: Gga.9471.1.S1_at (Chicken Array)   GgaAffx.10259.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050106
NCBI entrez gene - 395129     See in Manteia.
RefSeq - NM_001199447
RefSeq Peptide - NP_001186376
swissprot - A0A1D5PBH8
Ensembl - ENSGALG00000029983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt1ENSDARG00000030364Danio rerio
 ANGPT1ENSG00000154188Homo sapiens
 Angpt1ENSMUSG00000022309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANGPT4 / angiopoietin 4 / Q9WVH6* / Q9Y264*ENSGALG0000004075556
ANGPT2 / angiopoietin-2 / O15123* / O35608*ENSGALG0000003618950
ANGPTL1 / angiopoietin like 1 / O95841* / Q640P2* / Angiopoietin-related protein 1 *ENSGALG0000000429027
ANGPTL2 / angiopoietin like 2 / Q9R045* / Q9UKU9* / Angiopoietin-related protein 2 *ENSGALG0000000092725
FGL2 / fibrinogen like 2 / P12804* / Q14314* / Fibroleukin *ENSGALG0000000830624
ANGPTL7 / angiopoietin like 7 / O43827* / Q8R1Q3* / Angiopoietin-related protein 7 *ENSGALG0000000317923
FIBCD1 / fibrinogen C domain containing 1 / A2AV25* / Q8N539* / Fibrinogen C domain-containing protein 1 *ENSGALG0000000386619
ENSGALG0000001659919
FCN1* / FCN2* / Fcna* / Fcnb* / Q15485* / O70165* / O70497* / O00602* / ficolin 2* / ficolin 1*ENSGALG0000004077118


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028843  Angiopoietin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030210 heparin biosynthetic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0042308 negative regulation of protein import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048014 Tie signaling pathway IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072012 glomerulus vasculature development IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000446 regulation of macrophage migration inhibitory factor signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000020703 GRB14 / growth factor receptor bound protein 14 / Q14449* / Q9JLM9*  / complex / reaction
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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