ENSGALG00000027791


Gallus gallus

Features
Gene ID: ENSGALG00000027791
  
Biological name :FGF23
  
Synonyms : FGF23 / fibroblast growth factor 23
  
Possible biological names infered from orthology : Q9EPC2 / Q9GZV9
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 73192230
Gene end: 73195635
  
Corresponding Affymetrix probe sets: GgaAffx.11083.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042002
NCBI entrez gene - 428104     See in Manteia.
RefSeq - XM_425663
swissprot - R4GIR0
Ensembl - ENSGALG00000027791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf23ENSDARG00000045854Danio rerio
 FGF23ENSG00000118972Homo sapiens
 Fgf23ENSMUSG00000000182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *ENSGALG0000002837623


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028304  Fibroblast growth factor 23


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010966 regulation of phosphate transport IEA
 biological_processGO:0010980 positive regulation of vitamin D 24-hydroxylase activity IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030643 cellular phosphate ion homeostasis IEA
 biological_processGO:0042369 vitamin D catabolic process IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0055062 phosphate ion homeostasis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR2
Phospholipase C-mediated cascade; FGFR3
Downstream signaling of activated FGFR1
FRS-mediated FGFR1 signaling
Negative regulation of FGFR3 signaling
FRS-mediated FGFR4 signaling
Phospholipase C-mediated cascade; FGFR4
FGFR1c ligand binding and activation
FGFR4 ligand binding and activation
Phospholipase C-mediated cascade; FGFR2
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Negative regulation of FGFR1 signaling
RAF/MAP kinase cascade
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR1
FGFR1c and Klotho ligand binding and activation
FGFR3c ligand binding and activation
PI3K Cascade
FGFRL1 modulation of FGFR1 signaling
FRS-mediated FGFR2 signaling
FGFR2c ligand binding and activation
Negative regulation of FGFR4 signaling
Negative regulation of FGFR2 signaling
PI-3K cascade:FGFR4
PI-3K cascade:FGFR3
Post-translational protein phosphorylation
Phospholipase C-mediated cascade: FGFR1
PIP3 activates AKT signaling
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
SHC-mediated cascade:FGFR4
SHC-mediated cascade:FGFR3
SHC-mediated cascade:FGFR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000010960 GALNT3 / polypeptide N-acetylgalactosaminyltransferase 3 / P70419* / Q14435*  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000008716 FLRT3 / F1NUK7 / Leucine-rich repeat transmembrane protein FLRT3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*  / complex / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSGALG00000010589 FLRT2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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