ENSGALG00000009898


Gallus gallus

Features
Gene ID: ENSGALG00000009898
  
Biological name :GAB1
  
Synonyms : GAB1 / GRB2 associated binding protein 1
  
Possible biological names infered from orthology : Q13480 / Q9QYY0
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 30725096
Gene end: 30824645
  
Corresponding Affymetrix probe sets: Gga.15954.1.S1_at (Chicken Array)   Gga.19508.1.S1_s_at (Chicken Array)   GgaAffx.23069.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016076
Ensembl peptide - ENSGALP00000057486
Ensembl peptide - ENSGALP00000052970
Ensembl peptide - ENSGALP00000049658
NCBI entrez gene - 422456     See in Manteia.
RefSeq - XM_420422
RefSeq - XM_001232601
RefSeq - XM_004940952
RefSeq - XM_015276723
RefSeq - XM_015276724
swissprot - A0A1D5PJH6
swissprot - A0A1D5PA98
swissprot - F1NHL8
swissprot - A0A1D5PWZ6
Ensembl - ENSGALG00000009898
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gab1ENSDARG00000037018Danio rerio
 GAB1ENSG00000109458Homo sapiens
 Gab1ENSMUSG00000031714Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAB3 / GRB2 associated binding protein 3 / Q8BSM5* / Q8WWW8*ENSGALG0000000840822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0090668 endothelial cell chemotaxis to vascular endothelial growth factor IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000006390 CRKL / CRK like proto-oncogene, adaptor protein / P46109* / P47941* / Crk-like protein *  / complex / reaction
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / complex / reaction
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSGALG00000026944 ARF6 / P26990 / ADP-ribosylation factor 6 / P62330* / P62331*  / complex
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / complex / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction






 

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