ENSGALG00000008432


Gallus gallus

Features
Gene ID: ENSGALG00000008432
  
Biological name :AP2M1
  
Synonyms : AP-2 complex subunit mu / AP2M1 / Q5ZMP6
  
Possible biological names infered from orthology : adaptor related protein complex 2 mu 1 subunit / P84091 / Q96CW1
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 15866405
Gene end: 15889107
  
Corresponding Affymetrix probe sets: Gga.15365.1.S1_s_at (Chicken Array)   GgaAffx.11441.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000061320
Ensembl peptide - ENSGALP00000013724
NCBI entrez gene - 770246     See in Manteia.
RefSeq - XM_015291447
RefSeq - NM_001079494
RefSeq - XM_015291444
RefSeq - XM_015291445
RefSeq - XM_015291446
RefSeq - XM_015291442
RefSeq - XM_015291443
RefSeq Peptide - NP_001072962
swissprot - Q5ZMP6
swissprot - A0A1L1RR84
Ensembl - ENSGALG00000008432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2m1aENSDARG00000002790Danio rerio
 ap2m1bENSDARG00000033899Danio rerio
 AP2M1ENSG00000161203Homo sapiens
 Ap2m1ENSMUSG00000022841Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1M1ENSGALG0000000395939
AP3M1 / AP-3 complex subunit mu-1 / Q9JKC8* / Q9Y2T2* / adaptor related protein complex 3 mu 1 subunit*ENSGALG0000000507025
AP3M2 / adaptor related protein complex 3 mu 2 subunit / P53677* / Q8R2R9* / AP-3 complex subunit mu-2 *ENSGALG0000003815525


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003344 CLTB / clathrin light chain B / P09497* / Q6IRU5*  / complex / reaction
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000004594 CD74 / CD74 molecule / P04233* / P04441* / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex / reaction
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSGALG00000010166 VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*  / complex
 ENSGALG00000015898 MYO6 / unconventional myosin-VI / Q9UM54* / myosin VI*  / complex / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSGALG00000034168 WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*  / complex
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSGALG00000041823 PICK1 / protein interacting with PRKCA 1 / Q9NRD5* / protein interacting with C kinase 1*  / reaction
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction






 

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