ENSGALG00000043535


Gallus gallus

Features
Gene ID: ENSGALG00000043535
  
Biological name :RIPK2
  
Synonyms : receptor-interacting serine/threonine-protein kinase 2 / RIPK2
  
Possible biological names infered from orthology : O43353 / P58801 / receptor interacting serine/threonine kinase 2 / receptor (TNFRSF)-interacting serine-threonine kinase 2
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 124817881
Gene end: 124838867
  
Corresponding Affymetrix probe sets: GgaAffx.10124.2.S1_at (Chicken Array)   GgaAffx.10124.2.S1_s_at (Chicken Array)   GgaAffx.12451.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046771
Ensembl peptide - ENSGALP00000063334
Ensembl peptide - ENSGALP00000055145
NCBI entrez gene - 420215     See in Manteia.
RefSeq - NM_001030943
RefSeq Peptide - NP_001026114
swissprot - A0A1L1RWW2
swissprot - A0A1D5PQI0
swissprot - A0A1D5P276
Ensembl - ENSGALG00000043535
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk2ENSDARG00000104290Danio rerio
 RIPK2ENSG00000104312Homo sapiens
 Ripk2ENSMUSG00000041135Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RIPK4 / receptor interacting serine/threonine kinase 4 / P57078* / Q9ERK0* / Receptor-interacting serine/threonine-protein kinase 4 *ENSGALG0000004018924
ANKK1 / ankyrin repeat and kinase domain containing 1 / Q8BZ25* / Q8NFD2* / Ankyrin repeat and protein kinase domain-containing protein 1 *ENSGALG0000000781523
RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *ENSGALG0000001282718
ENSGALG0000004446614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001315  CARD domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017322  Receptor-interacting serine/threonine-protein kinase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0033091 positive regulation of immature T cell proliferation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0070671 response to interleukin-12 IEA
 biological_processGO:0070673 response to interleukin-18 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071224 cellular response to peptidoglycan IEA
 biological_processGO:0071225 cellular response to muramyl dipeptide IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:1904417 positive regulation of xenophagy IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050700 CARD domain binding IEA
 molecular_functionGO:0089720 caspase binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
p75NTR recruits signalling complexes
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex / reaction
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex / reaction
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction
 ENSGALG00000036807 NOD1 / Gallus gallus nucleotide binding oligomerization domain containing 1 (NOD1), mRNA. / Q8BHB0* / Q9Y239* / nucleotide binding oligomerization domain containing 1* / Nucleotide-binding ...  / complex / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex






 

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