ENSGALG00000012827


Gallus gallus

Features
Gene ID: ENSGALG00000012827
  
Biological name :RIPK1
  
Synonyms : receptor interacting serine/threonine kinase 1 / RIPK1
  
Possible biological names infered from orthology : Q13546 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 66550021
Gene end: 66570241
  
Corresponding Affymetrix probe sets: Gga.5199.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036418
Ensembl peptide - ENSGALP00000020891
NCBI entrez gene - 378921     See in Manteia.
RefSeq - XM_015275820
RefSeq - NM_204402
RefSeq - XM_015275818
RefSeq - XM_015275819
RefSeq Peptide - NP_989733
swissprot - F1P4C2
swissprot - E1C526
Ensembl - ENSGALG00000012827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk1lENSDARG00000006677Danio rerio
 RIPK1ENSG00000137275Homo sapiens
 Ripk1ENSMUSG00000021408Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANKK1 / ankyrin repeat and kinase domain containing 1 / Q8BZ25* / Q8NFD2* / Ankyrin repeat and protein kinase domain-containing protein 1 *ENSGALG0000000781516
RIPK4 / receptor interacting serine/threonine kinase 4 / P57078* / Q9ERK0* / Receptor-interacting serine/threonine-protein kinase 4 *ENSGALG0000004018916
RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*ENSGALG0000004353515
ENSGALG000000444666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007257 activation of JUN kinase activity IBA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060545 positive regulation of necroptotic process IEA
 biological_processGO:0070231 T cell apoptotic process IEA
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070926 regulation of ATP:ADP antiporter activity IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097343 ripoptosome assembly IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1901026 ripoptosome assembly involved in necroptotic process IEA
 biological_processGO:1905206 positive regulation of hydrogen peroxide-induced cell death IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0097342 ripoptosome IEA
 molecular_functionGO:0004672 protein kinase activity IBA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0070513 death domain binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008240 CFLAR / CASP8 and FADD-like apoptosis regulator / O15519* / O35732* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apopto...  / complex / reaction
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / complex / reaction
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSGALG00000013861 TNFAIP3 / TNF alpha induced protein 3 / P21580* / Q60769* / tumor necrosis factor, alpha-induced protein 3*  / complex
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex / reaction
 ENSGALG00000003753 CYLD / CYLD lysine 63 deubiquitinase / Q80TQ2* / Q9NQC7* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction






 

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