ENSGALG00000006418


Gallus gallus

Features
Gene ID: ENSGALG00000006418
  
Biological name :PDPK1
  
Synonyms : 3-phosphoinositide dependent protein kinase 1 / PDPK1
  
Possible biological names infered from orthology : O15530 / Q9Z2A0
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 7382465
Gene end: 7412949
  
Corresponding Affymetrix probe sets: Gga.1265.1.S1_a_at (Chicken Array)   Gga.1265.3.S1_at (Chicken Array)   GgaAffx.21495.1.S1_at (Chicken Array)   GgaAffx.21933.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052898
Ensembl peptide - ENSGALP00000010345
NCBI entrez gene - 416588     See in Manteia.
RefSeq - XM_015294215
RefSeq - NM_001012529
RefSeq - XM_015294212
RefSeq - XM_015294213
RefSeq - XM_015294214
RefSeq - XM_015294208
RefSeq - XM_015294209
RefSeq - XM_015294210
RefSeq - XM_015294211
RefSeq Peptide - NP_001012547
swissprot - Q5F3U4
swissprot - A0A1D5PJA6
Ensembl - ENSGALG00000006418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdpk1aENSDARG00000062304Danio rerio
 pdpk1bENSDARG00000018285Danio rerio
 PDPK1ENSG00000140992Homo sapiens
 Pdpk1ENSMUSG00000024122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SYL1* / SGK494* / BC030499* / uncharacterized serine/threonine-protein kinase SgK494*ENSGALG0000002770312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033931  PDK1-type, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0010518 positive regulation of phospholipase activity IEA
 biological_processGO:0010594 regulation of endothelial cell migration IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043304 regulation of mast cell degranulation IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004676 3-phosphoinositide-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016004 phospholipase activator activity IEA
 molecular_functionGO:0043274 phospholipase binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate PKNs
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / complex / reaction
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / complex / reaction
 ENSGALG00000001270 PRKCZ / protein kinase C zeta / Q02956* / Q05513*  / reaction
 ENSGALG00000002016 PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSGALG00000007097 RPS6KA6 / ribosomal protein S6 kinase A6 / Q9UK32* / ribosomal protein S6 kinase polypeptide 6*  / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000013971 SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex / reaction
 ENSGALG00000034970 PRKCQ / protein kinase C theta / Q02111* / Q04759*  / reaction
 ENSGALG00000025950 PRKCA / protein kinase C alpha / P17252*  / reaction
 ENSGALG00000037136 P18652 / RPS6KA1L / Ribosomal protein S6 kinase 2 alpha / Q15418* / P18653* / RPS6KA1* / ribosomal protein S6 kinase A1* / ribosomal protein S6 kinase polypeptide 1*  / reaction
 ENSGALG00000037943 PRKCB / protein kinase C beta / P05771* / P68404*  / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / reaction
 ENSGALG00000030063 MALT1 / MALT1 paracaspase / Q2TBA3* / Q9UDY8* / Mucosa-associated lymphoid tissue lymphoma translocation *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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