ENSDARG00000018285


Danio rerio

Features
Gene ID: ENSDARG00000018285
  
Biological name :pdpk1b
  
Synonyms : 3-phosphoinositide dependent protein kinase 1b / pdpk1b
  
Possible biological names infered from orthology : 3-phosphoinositide dependent protein kinase 1 / O15530 / PDPK1 / Q9Z2A0
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 37301852
Gene end: 37326236
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000019085
NCBI entrez gene - 403000     See in Manteia.
RefSeq - NM_205699
RefSeq Peptide - NP_991262
swissprot - Q6NZV1
ZFIN ID - ZDB-GENE-040426-1820
Ensembl - ENSDARG00000018285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDPK1ENSGALG00000006418Gallus gallus
 PDPK1ENSG00000140992Homo sapiens
 Pdpk1ENSMUSG00000024122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdpk1a / 3-phosphoinositide dependent protein kinase 1a / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*ENSDARG0000006230474
sgk494a / uncharacterized serine/threonine-protein kinase SgK494a / SGK494* / Q5SYL1* / BC030499* / uncharacterized serine/threonine-protein kinase SgK494*ENSDARG0000008717619
sgk494b / uncharacterized serine/threonine-protein kinase SgK494b / SGK494* / uncharacterized serine/threonine-protein kinase SgK494*ENSDARG0000008616917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033931  PDK1-type, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005622 intracellular IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin alphaIIb beta3 signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008723 prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*  / reaction
 ENSDARG00000018328 rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / complex / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000037574 rps6kal / ribosomal protein S6 kinase a, like / Q9UK32* / RPS6KA6* / ribosomal protein S6 kinase A6* / ribosomal protein S6 kinase polypeptide 6*  / reaction
 ENSDARG00000022254 prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*  / reaction
 ENSDARG00000025522 sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *  / reaction
 ENSDARG00000009208 prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSDARG00000034173 prkcq / protein kinase C, theta / Q02111* / Q04759*  / reaction
 ENSDARG00000011219 akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*  / reaction
 ENSDARG00000028469 rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSDARG00000021309 rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000043332 prkcz / protein kinase C, zeta / Q02956* / Q05513*  / reaction
 ENSDARG00000070651 prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*  / reaction
 ENSDARG00000099841 PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*  / reaction
 ENSDARG00000101293 zgc:153916 / PKN2 (1 of many) / PKN2* / Q16513* / protein kinase N2*  / complex / reaction
 ENSDARG00000101983 pkn2 / protein kinase N2 / Q16513*  / complex / reaction
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000077130 bcl10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex / reaction
 ENSDARG00000077768 malt1 / MALT paracaspase 1 / Q2TBA3* / Q9UDY8* / MALT1 paracaspase* / Mucosa-associated lymphoid tissue lymphoma translocation *  / complex / reaction






 

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