ENSDARG00000062304


Danio rerio

Features
Gene ID: ENSDARG00000062304
  
Biological name :pdpk1a
  
Synonyms : 3-phosphoinositide dependent protein kinase 1a / pdpk1a
  
Possible biological names infered from orthology : 3-phosphoinositide dependent protein kinase 1 / O15530 / PDPK1 / Q9Z2A0
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 45283391
Gene end: 45308394
  
Corresponding Affymetrix probe sets: Dr.14383.1.A1_at (Zebrafish Array)   Dr.7870.1.A1_at (Zebrafish Array)   NM_001077344_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000093021
Ensembl peptide - ENSDARP00000129062
NCBI entrez gene - 768202     See in Manteia.
RefSeq - NM_001077344
RefSeq Peptide - NP_001070812
swissprot - F1R447
swissprot - X1WFQ8
ZFIN ID - ZDB-GENE-061013-109
Ensembl - ENSDARG00000062304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDPK1ENSGALG00000006418Gallus gallus
 PDPK1ENSG00000140992Homo sapiens
 Pdpk1ENSMUSG00000024122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*ENSDARG0000001828575
sgk494b / uncharacterized serine/threonine-protein kinase SgK494b / SGK494* / uncharacterized serine/threonine-protein kinase SgK494*ENSDARG0000008616918
sgk494a / uncharacterized serine/threonine-protein kinase SgK494a / SGK494* / Q5SYL1* / BC030499* / uncharacterized serine/threonine-protein kinase SgK494*ENSDARG0000008717618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033931  PDK1-type, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005622 intracellular IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin alphaIIb beta3 signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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