ENSG00000140992


Homo sapiens

Features
Gene ID: ENSG00000140992
  
Biological name :PDPK1
  
Synonyms : 3-phosphoinositide dependent protein kinase 1 / O15530 / PDPK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 2537964
Gene end: 2603188
  
Corresponding Affymetrix probe sets: 204524_at (Human Genome U133 Plus 2.0 Array)   221244_s_at (Human Genome U133 Plus 2.0 Array)   224986_s_at (Human Genome U133 Plus 2.0 Array)   244629_s_at (Human Genome U133 Plus 2.0 Array)   244630_at (Human Genome U133 Plus 2.0 Array)   32029_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455551
Ensembl peptide - ENSP00000455492
Ensembl peptide - ENSP00000455684
Ensembl peptide - ENSP00000268673
Ensembl peptide - ENSP00000344220
Ensembl peptide - ENSP00000373876
Ensembl peptide - ENSP00000395357
Ensembl peptide - ENSP00000455025
Ensembl peptide - ENSP00000455438
NCBI entrez gene - 5170     See in Manteia.
OMIM - 605213
RefSeq - XM_017023277
RefSeq - NM_002613
RefSeq - NM_031268
RefSeq - XM_011522521
RefSeq - XM_011522523
RefSeq - XM_017023271
RefSeq - XM_017023272
RefSeq - XM_017023273
RefSeq - XM_017023274
RefSeq - XM_017023275
RefSeq - XM_017023276
RefSeq - NM_001261816
RefSeq Peptide - NP_002604
RefSeq Peptide - NP_112558
RefSeq Peptide - NP_001248745
swissprot - H3BQ10
swissprot - H3BQA3
swissprot - H3BNV5
swissprot - O15530
swissprot - E9PER6
swissprot - H3BPR5
swissprot - H3BPW1
Ensembl - ENSG00000140992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdpk1aENSDARG00000062304Danio rerio
 pdpk1bENSDARG00000018285Danio rerio
 PDPK1ENSGALG00000006418Gallus gallus
 Pdpk1ENSMUSG00000024122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SGK494 / uncharacterized serine/threonine-protein kinase SgK494ENSG0000016752416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033931  PDK1-type, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0010518 positive regulation of phospholipase activity IMP
 biological_processGO:0010594 regulation of endothelial cell migration IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032148 activation of protein kinase B activity TAS
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043304 regulation of mast cell degranulation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IMP
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004676 3-phosphoinositide-dependent protein kinase activity IDA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016004 phospholipase activator activity IMP
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043274 phospholipase binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin alphaIIb beta3 signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / complex / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000118515 SGK1 / O00141 / serum/glucocorticoid regulated kinase 1  / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / reaction
 ENSG00000071242 Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2  / reaction
 ENSG00000072133 Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6  / reaction
 ENSG00000166501 PRKCB / P05771 / protein kinase C beta  / reaction
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / complex / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / complex / reaction
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / complex / reaction
 ENSG00000117676 Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1  / reaction
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex / reaction
 ENSG00000177189 P51812 / RPS6KA3 / ribosomal protein S6 kinase A3  / reaction
 ENSG00000067606 PRKCZ / Q05513 / protein kinase C zeta  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / complex / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / complex / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction
 ENSG00000065243 PKN2 / Q16513 / protein kinase N2  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction






 

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