Manteia

ENSG00000155366

Homo sapiens

Features

Gene ID:	ENSG00000155366

Biological name :	RHOC

Synonyms :	P08134 / ras homolog family member C / RHOC

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	1
Strand:	-1
Band:	p13.2
Gene start:	112701106
Gene end:	112707434

Corresponding Affymetrix probe sets:	200885_at (Human Genome U133 Plus 2.0 Array) 235742_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000399424 Ensembl peptide - ENSP00000431392 Ensembl peptide - ENSP00000436240 Ensembl peptide - ENSP00000434877 Ensembl peptide - ENSP00000434310 Ensembl peptide - ENSP00000432209 Ensembl peptide - ENSP00000285735 Ensembl peptide - ENSP00000345236 Ensembl peptide - ENSP00000358646 Ensembl peptide - ENSP00000358647 Ensembl peptide - ENSP00000358650 Ensembl peptide - ENSP00000358651 Ensembl peptide - ENSP00000358652 Ensembl peptide - ENSP00000358656 Ensembl peptide - ENSP00000390823 Ensembl peptide - ENSP00000395791 NCBI entrez gene - 389 See in Manteia. OMIM - 165380 RefSeq - NM_001042678 RefSeq - NM_001042679 RefSeq - NM_175744 RefSeq Peptide - NP_786886 RefSeq Peptide - NP_001036143 RefSeq Peptide - NP_001036144 swissprot - Q5JR06 swissprot - Q5JR07 swissprot - E9PQH6 swissprot - Q5JR08 swissprot - E9PN11 swissprot - E9PLA2 swissprot - A0A024R0I3 swissprot - P08134 swissprot - Q5JR05 Ensembl - ENSG00000155366

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rhoca	ENSDARG00000021309	Danio rerio
rhocb	ENSDARG00000018328	Danio rerio
RHOC	ENSGALG00000001569	Gallus gallus
Rhoc	ENSMUSG00000002233	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RHOA / P61586 / ras homolog family member A	ENSG00000067560	92
RHOB / P62745 / ras homolog family member B	ENSG00000143878	84
AL603832.3	ENSG00000271810	55
RHOD / O00212 / ras homolog family member D	ENSG00000173156	50
RND3 / P61587 / Rho family GTPase 3	ENSG00000115963	49
RHOF / Q9HBH0 / ras homolog family member F, filopodia associated	ENSG00000139725	49
RND2 / P52198 / Rho family GTPase 2	ENSG00000108830	47
RND1 / Q92730 / Rho family GTPase 1	ENSG00000172602	43

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR003578	Small GTPase superfamily, Rho type
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000281	mitotic cytokinesis	IDA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0032464	positive regulation of protein homooligomerization	ISS
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP
biological_process	GO:0043297	apical junction assembly	IDA
biological_process	GO:0044319	wound healing, spreading of cells	ISS
biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	TAS
biological_process	GO:0060193	positive regulation of lipase activity	IDA
biological_process	GO:1902766	skeletal muscle satellite cell migration	ISS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0032154	cleavage furrow	IEA
cellular_component	GO:0032420	stereocilium	ISS
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	HMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	IEA

Pathways (from Reactome)

Pathway description

Rho GTPase cycle

G alpha (12/13) signalling events

Sema4D induced cell migration and growth-cone collapse

RHO GTPases activate PKNs

RHO GTPases activate CIT

RHO GTPases Activate ROCKs

RHO GTPases Activate Formins

RHO GTPases Activate Rhotekin and Rhophilins

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000114993	RTKN / Q9BST9 / rhotekin	/ complex / reaction
ENSG00000122966	CIT / O14578 / citron rho-interacting serine/threonine kinase	/ complex / reaction
ENSG00000164050	O43157 / PLXNB1 / plexin B1	/ reaction
ENSG00000132535	DLG4 / P78352 / discs large MAGUK scaffold protein 4	/ complex / reaction
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ reaction
ENSG00000172602	RND1 / Q92730 / Rho family GTPase 1	/ reaction
ENSG00000100345	MYH9 / P35579 / myosin heavy chain 9	/ reaction
ENSG00000123143	PKN1 / Q16512 / protein kinase N1	/ complex / reaction
ENSG00000118680	MYL12B / O14950 / myosin light chain 12B	/ reaction
ENSG00000058272	O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A	/ reaction
ENSG00000105357	MYH14 / Q7Z406 / myosin heavy chain 14	/ reaction
ENSG00000134318	ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2	/ complex / reaction
ENSG00000140992	PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1	/ complex / reaction
ENSG00000077157	O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B	/ reaction
ENSG00000101335	MYL9 / P24844 / myosin light chain 9	/ reaction
ENSG00000092841	MYL6 / P60660 / myosin light chain 6	/ reaction
ENSG00000213639	P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta	/ reaction
ENSG00000133392	MYH11 / P35749 / myosin heavy chain 11	/ reaction
ENSG00000133026	MYH10 / P35580 / myosin heavy chain 10	/ reaction
ENSG00000161791	FMNL3 / Q8IVF7 / formin like 3	/ complex / reaction
ENSG00000106683	LIMK1 / P53667 / LIM domain kinase 1	/ reaction
ENSG00000184009	ACTG1 / P63261 / actin gamma 1	/ complex / reaction
ENSG00000065243	PKN2 / Q16513 / protein kinase N2	/ complex / reaction
ENSG00000075624	ACTB / P60709 / actin beta	/ complex / reaction
ENSG00000118193	KIF14 / Q15058 / kinesin family member 14	/ complex / reaction
ENSG00000067900	ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1	/ complex / reaction
ENSG00000157827	FMNL2 / Q96PY5 / formin like 2	/ complex / reaction
ENSG00000187764	Q92854 / SEMA4D / semaphorin 4D	/ reaction
ENSG00000132694	O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11	/ reaction
ENSG00000196914	Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12	/ reaction
ENSG00000198901	PRC1 / O43663 / protein regulator of cytokinesis 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr