Manteia

ENSG00000132535

Homo sapiens

Features

Gene ID:	ENSG00000132535

Biological name :	DLG4

Synonyms :	discs large MAGUK scaffold protein 4 / DLG4 / P78352

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	p13.1
Gene start:	7189890
Gene end:	7219702

Corresponding Affymetrix probe sets:	204592_at (Human Genome U133 Plus 2.0 Array) 210684_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000465720 Ensembl peptide - ENSP00000460625 Ensembl peptide - ENSP00000465789 Ensembl peptide - ENSP00000467897 Ensembl peptide - ENSP00000307471 Ensembl peptide - ENSP00000382425 Ensembl peptide - ENSP00000382428 Ensembl peptide - ENSP00000388122 Ensembl peptide - ENSP00000407918 NCBI entrez gene - 1742 See in Manteia. OMIM - 602887 RefSeq - XM_017024290 RefSeq - NM_001128827 RefSeq - NM_001321074 RefSeq - NM_001321075 RefSeq - NM_001321076 RefSeq - NM_001321077 RefSeq - NM_001365 RefSeq - XM_005256491 RefSeq - XM_011523698 RefSeq - XM_011523699 RefSeq - XM_011523702 RefSeq - XM_017024288 RefSeq - XM_017024289 RefSeq Peptide - NP_001308003 RefSeq Peptide - NP_001308005 RefSeq Peptide - NP_001308006 RefSeq Peptide - NP_001356 RefSeq Peptide - NP_001122299 RefSeq Peptide - NP_001308004 swissprot - P78352 swissprot - C9JWP9 swissprot - C9JYG3 swissprot - K7EKP9 swissprot - K7EKU8 swissprot - K7EQM6 swissprot - O14909 Ensembl - ENSG00000132535

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dlg4a	ENSDARG00000041926	Danio rerio
Dlg4	ENSMUSG00000020886	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
DLG1 / Q12959 / discs large MAGUK scaffold protein 1	ENSG00000075711	73
DLG2 / Q15700 / discs large MAGUK scaffold protein 2	ENSG00000150672	68
DLG3 / Q92796 / discs large MAGUK scaffold protein 3	ENSG00000082458	62
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5	ENSG00000151208	24
MPP5 / Q8N3R9 / membrane palmitoylated protein 5	ENSG00000072415	20
TJP1 / Q07157 / tight junction protein 1	ENSG00000104067	20
TJP3 / O95049 / tight junction protein 3	ENSG00000105289	20
TJP2 / Q9UDY2 / tight junction protein 2	ENSG00000119139	20
AL358113.1	ENSG00000285130	20
MPP6 / Q9NZW5 / membrane palmitoylated protein 6	ENSG00000105926	19
MPP2 / Q14168 / membrane palmitoylated protein 2	ENSG00000108852	19
MPP7 / Q5T2T1 / membrane palmitoylated protein 7	ENSG00000150054	19
MPP4 / Q96JB8 / membrane palmitoylated protein 4	ENSG00000082126	18
CASK / O14936 / calcium/calmodulin dependent serine protein kinase	ENSG00000147044	18
MPP3 / Q13368 / membrane palmitoylated protein 3	ENSG00000161647	18
MPP1 / Q00013 / membrane palmitoylated protein 1	ENSG00000130830	15
GUK1 / Q16774 / guanylate kinase 1	ENSG00000143774	9

Protein motifs (from Interpro)

Interpro ID	Name
IPR001452	SH3 domain
IPR001478	PDZ domain
IPR008144	Guanylate kinase-like domain
IPR008145	Guanylate kinase/L-type calcium channel beta subunit
IPR016313	Disks large 1-like
IPR019583	PDZ-associated domain of NMDA receptors
IPR019590	Disks large homologue 1, N-terminal PEST domain
IPR020590	Guanylate kinase, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR036028	SH3-like domain superfamily
IPR036034	PDZ superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0002091	negative regulation of receptor internalization	ISS
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISS
biological_process	GO:0007268	chemical synaptic transmission	TAS
biological_process	GO:0007399	nervous system development	TAS
biological_process	GO:0007612	learning	TAS
biological_process	GO:0016188	synaptic vesicle maturation	IEA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0035176	social behavior	IEA
biological_process	GO:0035418	protein localization to synapse	IEA
biological_process	GO:0035641	locomotory exploration behavior	IEA
biological_process	GO:0045184	establishment of protein localization	IDA
biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	IBA
biological_process	GO:0046037	GMP metabolic process	IEA
biological_process	GO:0046710	GDP metabolic process	IEA
biological_process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IEA
biological_process	GO:0050806	positive regulation of synaptic transmission	ISS
biological_process	GO:0050885	neuromuscular process controlling balance	IEA
biological_process	GO:0060997	dendritic spine morphogenesis	IEA
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	TAS
biological_process	GO:0065003	protein-containing complex assembly	IDA
biological_process	GO:0071625	vocalization behavior	IEA
biological_process	GO:0097113	AMPA glutamate receptor clustering	TAS
biological_process	GO:0097120	receptor localization to synapse	IBA
biological_process	GO:0150012	positive regulation of neuron projection arborization	ISS
biological_process	GO:2000310	regulation of NMDA receptor activity	ISS
biological_process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISS
biological_process	GO:2000821	regulation of grooming behavior	IEA
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0008021	synaptic vesicle	IEA
cellular_component	GO:0008076	voltage-gated potassium channel complex	ISS
cellular_component	GO:0008328	ionotropic glutamate receptor complex	IEA
cellular_component	GO:0014069	postsynaptic density	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	IBA
cellular_component	GO:0030054	cell junction	ISS
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0030666	endocytic vesicle membrane	TAS
cellular_component	GO:0030863	cortical cytoskeleton	IDA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA
cellular_component	GO:0032281	AMPA glutamate receptor complex	IEA
cellular_component	GO:0032839	dendrite cytoplasm	ISS
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043197	dendritic spine	IEA
cellular_component	GO:0044224	juxtaparanode region of axon	IEA
cellular_component	GO:0044300	cerebellar mossy fiber	IEA
cellular_component	GO:0044306	neuron projection terminus	IEA
cellular_component	GO:0044309	neuron spine	IEA
cellular_component	GO:0045202	synapse	IDA
cellular_component	GO:0045211	postsynaptic membrane	IEA
cellular_component	GO:0060076	excitatory synapse	IEA
cellular_component	GO:0071944	cell periphery	IEA
cellular_component	GO:0097060	synaptic membrane	IEA
cellular_component	GO:0098794	postsynapse	IEA
cellular_component	GO:0098839	postsynaptic density membrane	IEA
molecular_function	GO:0004385	guanylate kinase activity	IBA
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008022	protein C-terminus binding	IPI
molecular_function	GO:0015276	ligand-gated ion channel activity	TAS
molecular_function	GO:0019900	kinase binding	IDA
molecular_function	GO:0019903	protein phosphatase binding	ISS
molecular_function	GO:0030165	PDZ domain binding	ISS
molecular_function	GO:0031697	beta-1 adrenergic receptor binding	ISS
molecular_function	GO:0031748	D1 dopamine receptor binding	ISS
molecular_function	GO:0031812	P2Y1 nucleotide receptor binding	ISS
molecular_function	GO:0033130	acetylcholine receptor binding	ISS
molecular_function	GO:0035255	ionotropic glutamate receptor binding	IEA
molecular_function	GO:0044877	protein-containing complex binding	ISS
molecular_function	GO:0097109	neuroligin family protein binding	ISS
molecular_function	GO:0097110	scaffold protein binding	IEA

Pathways (from Reactome)

Pathway description

Trafficking of AMPA receptors

Unblocking of NMDA receptor, glutamate binding and activation

CREB phosphorylation through the activation of CaMKII

Ras activation upon Ca2+ influx through NMDA receptor

NrCAM interactions

Activation of Ca-permeable Kainate Receptor

RHO GTPases activate CIT

RAF/MAP kinase cascade

LGI-ADAM interactions

Neurexins and neuroligins

Synaptic adhesion-like molecules

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000006116	CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3	/ complex
ENSG00000033122	LRRC7 / Q96NW7 / leucine rich repeat containing 7	/ complex
ENSG00000128011	LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1	/ complex / reaction
ENSG00000116544	DLGAP3 / O95886 / DLG associated protein 3	/ complex / reaction
ENSG00000075461	CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4	/ complex
ENSG00000105464	GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D	/ complex / reaction
ENSG00000135679	MDM2 / Q00987 / MDM2 proto-oncogene	/ complex
ENSG00000122966	CIT / O14578 / citron rho-interacting serine/threonine kinase	/ complex / reaction
ENSG00000113319	O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2	/ complex / reaction
ENSG00000067560	RHOA / P61586 / ras homolog family member A	/ complex / reaction
ENSG00000120251	GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2	/ reaction
ENSG00000058404	CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta	/ complex / reaction
ENSG00000155511	GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1	/ reaction
ENSG00000152578	GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4	/ reaction
ENSG00000143878	RHOB / P62745 / ras homolog family member B	/ complex / reaction
ENSG00000161681	Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1	/ complex / reaction
ENSG00000082458	DLG3 / Q92796 / discs large MAGUK scaffold protein 3	/ complex
ENSG00000051128	HOMER3 / Q9NSC5 / homer scaffolding protein 3	/ complex / reaction
ENSG00000114948	ADAM23 / O75077 / ADAM metallopeptidase domain 23	/ complex / reaction
ENSG00000008277	ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22	/ complex
ENSG00000152822	GRM1 / Q13255 / glutamate metabotropic receptor 1	/ complex / reaction
ENSG00000168959	GRM5 / P41594 / glutamate metabotropic receptor 5	/ complex / reaction
ENSG00000150672	DLG2 / Q15700 / discs large MAGUK scaffold protein 2	/ complex
ENSG00000132535	DLG4 / P78352 / discs large MAGUK scaffold protein 4	/ complex
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000161509	GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C	/ complex / reaction
ENSG00000166862	CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2	/ complex
ENSG00000148660	CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma	/ complex / reaction
ENSG00000142408	CACNG8 / Q8WXS5 / calcium voltage-gated channel auxiliary subunit gamma 8	/ complex
ENSG00000152413	HOMER1 / Q86YM7 / homer scaffolding protein 1	/ complex / reaction
ENSG00000155366	RHOC / P08134 / ras homolog family member C	/ complex / reaction
ENSG00000103942	HOMER2 / Q9NSB8 / homer scaffolding protein 2	/ complex / reaction
ENSG00000145349	CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta	/ complex / reaction
ENSG00000163110	PDLIM5 / Q96HC4 / PDZ and LIM domain 5	/ complex / reaction
ENSG00000156564	LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2	/ complex / reaction
ENSG00000171189	GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1	/ complex
ENSG00000183454	GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A	/ complex / reaction
ENSG00000164418	GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2	/ complex
ENSG00000127914	AKAP9 / Q99996 / A-kinase anchoring protein 9	/ complex
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000070808	CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha	/ complex / reaction
ENSG00000176884	GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1	/ complex / reaction
ENSG00000198668	CALM1 / P0DP23 / calmodulin 1	/ complex / reaction
ENSG00000075711	DLG1 / Q12959 / discs large MAGUK scaffold protein 1	/ complex
ENSG00000091129	NRCAM / Q92823 / neuronal cell adhesion molecule	/ complex / reaction
ENSG00000149403	GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4	/ complex
ENSG00000163873	GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3	/ complex
ENSG00000077522	ACTN2 / P35609 / actinin alpha 2	/ complex
ENSG00000136279	DBNL / Q9UJU6 / drebrin like	/ complex / reaction
ENSG00000277586	NEFL / P07196 / neurofilament light	/ complex
ENSG00000273079	GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B	/ complex / reaction
ENSG00000173621	LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4	/ complex / reaction
ENSG00000170579	DLGAP1 / O14490 / DLG associated protein 1	/ complex / reaction
ENSG00000080845	DLGAP4 / Q9Y2H0 / DLG associated protein 4	/ complex / reaction
ENSG00000162105	Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2	/ complex / reaction
ENSG00000183092	BEGAIN / Q9BUH8 / brain enriched guanylate kinase associated	/ complex / reaction
ENSG00000197555	O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1	/ complex / reaction
ENSG00000108231	LGI1 / O95970 / leucine rich glioma inactivated 1	/ complex / reaction
ENSG00000058335	Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1	/ complex / reaction
ENSG00000198010	DLGAP2 / Q9P1A6 / DLG associated protein 2	/ complex / reaction
ENSG00000125675	GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr