ENSDARG00000028058


Danio rerio

Features
Gene ID: ENSDARG00000028058
  
Biological name :traf6
  
Synonyms : Q6IWL4 / TNF receptor-associated factor 6 / traf6
  
Possible biological names infered from orthology : P70196 / Q9Y4K3
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 48719924
Gene end: 48738807
  
Corresponding Affymetrix probe sets: Dr.15109.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000036715
Ensembl peptide - ENSDARP00000150477
Ensembl peptide - ENSDARP00000151579
NCBI entrez gene - 554561     See in Manteia.
swissprot - Q6IWL4
ZFIN ID - ZDB-GENE-030131-5735
Ensembl - ENSDARG00000028058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRAF6ENSGALG00000007932Gallus gallus
 TRAF6ENSG00000175104Homo sapiens
 Traf6ENSMUSG00000027164Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*ENSDARG0000003017324
traf2b / Tnf receptor-associated factor 2bENSDARG0000010103624
traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*ENSDARG0000002200023
traf1 / TNF receptor-associated factor 1 / P39428* / Q13077*ENSDARG0000006948223
traf4a / tnf receptor-associated factor 4a / TRAF4* / Q61382* / Q9BUZ4* / TNF receptor associated factor 4*ENSDARG0000000396320
traf4b / tnf receptor-associated factor 4bENSDARG0000003896420
traf5 / Tnf receptor-associated factor 5 / O00463*ENSDARG0000001724013
unm_sa808 / un-named sa808 / TRAF2* / Q12933* / TNF receptor associated factor 2*ENSDARG0000007837812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027139  TNF receptor-associated factor 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
MyD88:Mal cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
Regulated proteolysis of p75NTR
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000014770 usp4 / ubiquitin specific peptidase 4 (proto-oncogene) / P35123* / Q13107* / ubiquitin specific peptidase 4*  / reaction / complex
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / complex / reaction
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000021225 prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*  / complex / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / - / complex / reaction
 ENSDARG00000027777 tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / Q60769* / TNF alpha induced protein 3*  / complex
 ENSDARG00000034173 prkcq / protein kinase C, theta / Q02111* / Q04759*  / complex / reaction
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000077130 bcl10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex / reaction
 ENSDARG00000077768 malt1 / MALT paracaspase 1 / Q2TBA3* / Q9UDY8* / MALT1 paracaspase* / Mucosa-associated lymphoid tissue lymphoma translocation *  / complex / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex / reaction
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex
 ENSDARG00000060348 map3k3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*  / complex / reaction
 ENSDARG00000067672 card9 / caspase recruitment domain family, member 9 / Q9H257*  / complex / reaction
 ENSDARG00000060058 cylda / cylindromatosis (turban tumor syndrome), a / CYLD* / Q80TQ2* / Q9NQC7* / CYLD lysine 63 deubiquitinase* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / complex
 ENSDARG00000098405 map3k1 / mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase / Q13233* / mitogen-activated protein kinase kinase kinase 1*  / complex / reaction
 ENSDARG00000098486 tollip / toll interacting protein / Q9H0E2* / Q9QZ06*  / complex / reaction
 ENSDARG00000090844 CABZ01054965.1 / IL1R1* / Q9HB29* / IL1RL1* / IL1RL2* / P14778* / Q01638* / interleukin 1 receptor like 1* / interleukin 1 receptor like 2* / interleukin 1 receptor type 1*  / complex / reaction






 

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