ENSDARG00000014770


Danio rerio

Features
Gene ID: ENSDARG00000014770
  
Biological name :usp4
  
Synonyms : ubiquitin specific peptidase 4 (proto-oncogene) / usp4
  
Possible biological names infered from orthology : P35123 / Q13107 / ubiquitin specific peptidase 4
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 42345005
Gene end: 42369186
  
Corresponding Affymetrix probe sets: Dr.17553.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000039867
NCBI entrez gene - 449927     See in Manteia.
RefSeq - XM_002662510
swissprot - E7EZD6
ZFIN ID - ZDB-GENE-041008-187
Ensembl - ENSDARG00000014770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP4ENSGALG00000003799Gallus gallus
 USP4ENSG00000114316Homo sapiens
 Usp4ENSMUSG00000032612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp11 / ubiquitin specific peptidase 11 / P51784* / Q99K46*ENSDARG0000007630344
usp32 / ubiquitin specific peptidase 32 / USP6* / Q8NFA0* / P35125* / ubiquitin specific peptidase 6*ENSDARG0000006189529
usp19 / ubiquitin specific peptidase 19 / O94966* / Q3UJD6*ENSDARG0000000413226
usp31 / ubiquitin specific peptidase 31 / Q70CQ4*ENSDARG0000007401720
usp43b / ubiquitin specific peptidase 43b / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*ENSDARG0000008807220
usp43a / ubiquitin specific peptidase 43a / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*ENSDARG0000010349419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028135  Ubiquitin-like domain, USP-type
 IPR028889  Ubiquitin specific protease domain
 IPR029346  Ubiquitin carboxyl-terminal hydrolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism decreased life span , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000014770 usp4 / ubiquitin specific peptidase 4 (proto-oncogene) / P35123* / Q13107* / ubiquitin specific peptidase 4*  / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex






 

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