ENSDARG00000060348


Danio rerio

Features
Gene ID: ENSDARG00000060348
  
Biological name :map3k3
  
Synonyms : map3k3 / mitogen-activated protein kinase kinase kinase 3
  
Possible biological names infered from orthology : Q61084 / Q99759
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 31815184
Gene end: 31845816
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000079367
Ensembl peptide - ENSDARP00000129502
Ensembl peptide - ENSDARP00000147141
NCBI entrez gene - 560211     See in Manteia.
swissprot - E7EXX1
ZFIN ID - ZDB-GENE-070910-1
Ensembl - ENSDARG00000060348
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K3ENSGALG00000000525Gallus gallus
 MAP3K3ENSG00000198909Homo sapiens
 Map3k3ENSMUSG00000020700Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSDARG0000006288463
map3k1 / mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase / Q13233* / mitogen-activated protein kinase kinase kinase 1*ENSDARG0000009840525
map3k20 / mitogen-activated protein kinase kinase kinase 20ENSDARG0000007421921
map3k19 / mitogen-activated protein kinase kinase kinase 19 / E9Q3S4* / Q56UN5*ENSDARG0000009427220
map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*ENSDARG0000006171016
map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000007406016
arf2b / map3k14b / mitogen-activated protein kinase kinase kinase 14b / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000005658214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034879  Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex






 

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