ENSDARG00000089223


Danio rerio

Features
Gene ID: ENSDARG00000089223
  
Biological name :ngfrb
  
Synonyms : nerve growth factor receptor b / ngfrb
  
Possible biological names infered from orthology : nerve growth factor receptor / NGFR / P08138
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 9949941
Gene end: 10038870
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000126756
NCBI entrez gene - 564338     See in Manteia.
swissprot - E2DGP8
ZFIN ID - ZDB-GENE-070606-2
Ensembl - ENSDARG00000089223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NGFRENSGALG00000035950Gallus gallus
 NGFRENSG00000064300Homo sapiens
 NgfrENSMUSG00000000120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*ENSDARG0000008870840
nradd / neurotrophin receptor associated death domain / Q8CJ26* / Death domain-containing membrane protein NRADD *ENSDARG0000005714331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR022325  Tumour necrosis factor receptor 16
 IPR034046  Tumor necrosis factor receptor 16, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010977 negative regulation of neuron projection development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048916 posterior lateral line development IMP
 biological_processGO:0048922 posterior lateral line neuromast deposition IMP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048406 nerve growth factor binding IBA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium decreased size , abnormal
posterior lateral line primordium disorganized , abnormal
posterior lateral line primordium lacks parts or has fewer parts of type protoneuromast , abnormal
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 ZFA:0001472 anterior lateral line neuromast anterior lateral line neuromast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015540 psen2 / Q90ZE4 / presenilin 2 / P49810*  / reaction
 ENSDARG00000005612 aph1b / Q8JHE9 / APH1B gamma secretase subunit / Aph1c* / Q9DCZ9* / Q8C7N7* / Q8WW43* / Gamma-secretase subunit APH-1B * / Putative gamma-secretase subunit APH-1C * / aph-1 homolog B, gamma...  / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000068698 psenen / Q8JHF0 / presenilin enhancer gamma secretase subunit / Q9NZ42* / Q9CQR7* / AD000671.1* / Gamma-secretase subunit PEN-2 *  / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex
 ENSDARG00000021225 prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*  / complex / reaction
 ENSDARG00000035899 Q66HV9 / lingo1b / leucine rich repeat and Ig domain containing 1b / Q9D1T0* / LINGO1* / Q96FE5* / leucine rich repeat and Ig domain containing 1* / Leucine-rich repeat and immunoglobulin-l...  / complex / reaction
 ENSDARG00000034165 lingo1a / leucine rich repeat and Ig domain containing 1a / Q9D1T0* / LINGO1* / Q96FE5* / leucine rich repeat and Ig domain containing 1* / Leucine-rich repeat and immunoglobulin-like domai...  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000089444 omgb / oligodendrocyte myelin glycoprotein b / OMG* / P23515* / oligodendrocyte myelin glycoprotein*  / complex / reaction
 ENSDARG00000104023 mag / myelin associated glycoprotein / P20917* / P20916* / AC011452.1* / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA.*  / complex / reaction
 ENSDARG00000004870 psen1 / presenilin 1 / P49768* / P49769*  / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex / reaction






 

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