ENSG00000064300


Homo sapiens

Features
Gene ID: ENSG00000064300
  
Biological name :NGFR
  
Synonyms : nerve growth factor receptor / NGFR / P08138
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 49495293
Gene end: 49515017
  
Corresponding Affymetrix probe sets: 205858_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421731
Ensembl peptide - ENSP00000172229
Ensembl peptide - ENSP00000421514
NCBI entrez gene - 4804     See in Manteia.
OMIM - 162010
RefSeq - NM_002507
RefSeq Peptide - NP_002498
swissprot - P08138
Ensembl - ENSG00000064300
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfraENSDARG00000088708Danio rerio
 ngfrbENSDARG00000089223Danio rerio
 NGFRENSGALG00000035950Gallus gallus
 NgfrENSMUSG00000000120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR022325  Tumour necrosis factor receptor 16
 IPR034046  Tumor necrosis factor receptor 16, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010977 negative regulation of neuron projection development IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis TAS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050771 negative regulation of axonogenesis TAS
 biological_processGO:0050772 positive regulation of axonogenesis TAS
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IDA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
 biological_processGO:1904646 cellular response to amyloid-beta IDA
 biological_processGO:2001273 regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005035 death receptor activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0015026 coreceptor activity IDA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0043121 neurotrophin binding ISS
 molecular_functionGO:0048406 nerve growth factor binding IBA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000040608 RTN4R / Q9BZR6 / reticulon 4 receptor  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000126861 OMG / P23515 / oligodendrocyte myelin glycoprotein  / complex / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / complex / reaction
 ENSG00000135587 SMPD2 / O60906 / sphingomyelin phosphodiesterase 2  / reaction
 ENSG00000141522 P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000115310 RTN4 / Q9NQC3 / reticulon 4  / complex / reaction
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex / reaction
 ENSG00000169783 LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1  / complex / reaction
 ENSG00000105695 MAG / P20916 / myelin associated glycoprotein  / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000275700 AATF / Q9NY61 / apoptosis antagonizing transcription factor  / reaction / complex
 ENSG00000110851 PRDM4 / Q9UKN5 / PR/SET domain 4  / complex / reaction
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / complex / reaction
 ENSG00000205155 PSENEN / Q9NZ42 / presenilin enhancer gamma-secretase subunit  / reaction
 ENSG00000117362 APH1A / Q96BI3 / aph-1 homolog A, gamma-secretase subunit  / reaction
 ENSG00000138613 APH1B / Q8WW43 / aph-1 homolog B, gamma-secretase subunit  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000151694 ADAM17 / P78536 / ADAM metallopeptidase domain 17  / reaction
 ENSG00000142856 Q13352 / ITGB3BP / integrin subunit beta 3 binding protein  / complex / reaction
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex / reaction
 ENSG00000162736 NCSTN / Q92542 / nicastrin  / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000179222 MAGED1 / Q9Y5V3 / MAGE family member D1  / complex / reaction
 ENSG00000080815 PSEN1 / P49768 / presenilin 1  / reaction
 ENSG00000166681 BEX3 / Q00994 / brain expressed X-linked 3  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000143801 PSEN2 / P49810 / presenilin 2  / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction






 

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