ENSG00000107643


Homo sapiens

Features
Gene ID: ENSG00000107643
  
Biological name :MAPK8
  
Synonyms : MAPK8 / mitogen-activated protein kinase 8 / P45983
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q11.22
Gene start: 48306639
Gene end: 48439360
  
Corresponding Affymetrix probe sets: 210477_x_at (Human Genome U133 Plus 2.0 Array)   210671_x_at (Human Genome U133 Plus 2.0 Array)   226046_at (Human Genome U133 Plus 2.0 Array)   226048_at (Human Genome U133 Plus 2.0 Array)   229664_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363304
Ensembl peptide - ENSP00000363297
Ensembl peptide - ENSP00000378974
Ensembl peptide - ENSP00000397729
Ensembl peptide - ENSP00000393223
Ensembl peptide - ENSP00000387936
Ensembl peptide - ENSP00000353483
Ensembl peptide - ENSP00000363289
Ensembl peptide - ENSP00000363291
Ensembl peptide - ENSP00000363294
NCBI entrez gene - 5599     See in Manteia.
OMIM - 601158
RefSeq - NM_139046
RefSeq - NM_001278547
RefSeq - NM_001278548
RefSeq - NM_001323302
RefSeq - NM_001323320
RefSeq - NM_001323321
RefSeq - NM_001323322
RefSeq - NM_001323323
RefSeq - NM_001323324
RefSeq - NM_001323325
RefSeq - NM_001323326
RefSeq - NM_001323327
RefSeq - NM_001323328
RefSeq - NM_001323329
RefSeq - NM_001323330
RefSeq - NM_001323331
RefSeq - NM_139049
RefSeq Peptide - NP_001310260
RefSeq Peptide - NP_620637
RefSeq Peptide - NP_001310256
RefSeq Peptide - NP_001310257
RefSeq Peptide - NP_001310258
RefSeq Peptide - NP_001310259
RefSeq Peptide - NP_620634
RefSeq Peptide - NP_001265476
RefSeq Peptide - NP_001265477
RefSeq Peptide - NP_001310231
RefSeq Peptide - NP_001310249
RefSeq Peptide - NP_001310250
RefSeq Peptide - NP_001310251
RefSeq Peptide - NP_001310252
RefSeq Peptide - NP_001310253
RefSeq Peptide - NP_001310254
RefSeq Peptide - NP_001310255
swissprot - A1L4K2
swissprot - P45983
swissprot - C9J762
swissprot - A6NF29
swissprot - C9JWQ4
Ensembl - ENSG00000107643
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK8ENSGALG00000006109Gallus gallus
 Mapk8ENSMUSG00000021936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK10 / P53779 / mitogen-activated protein kinase 10ENSG0000010933990
MAPK9 / P45984 / mitogen-activated protein kinase 9ENSG0000005074882
MAPK11 / Q15759 / mitogen-activated protein kinase 11ENSG0000018538642
MAPK14 / Q16539 / mitogen-activated protein kinase 14ENSG0000011206241
MAPK12 / P53778 / mitogen-activated protein kinase 12ENSG0000018813040
MAPK13 / O15264 / mitogen-activated protein kinase 13ENSG0000015671139


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007258 JUN phosphorylation IDA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IMP
 biological_processGO:0031063 regulation of histone deacetylation IEA
 biological_processGO:0031281 positive regulation of cyclase activity IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051247 positive regulation of protein metabolic process IMP
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:0090045 positive regulation of deacetylase activity IMP
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1902595 regulation of DNA replication origin binding IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0097441 basal dendrite ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004705 JUN kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035033 histone deacetylase regulator activity IMP
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000142856 Q13352 / ITGB3BP / integrin subunit beta 3 binding protein  / reaction
 ENSG00000179222 MAGED1 / Q9Y5V3 / MAGE family member D1  / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000065559 MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4  / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000166313 APBB1 / O00213 / amyloid beta precursor protein binding family B member 1  / complex / reaction
 ENSG00000153094 O43521 / BCL2L11 / BCL2 like 11  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000104081 BMF / Q96LC9 / Bcl2 modifying factor  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000177606 JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunit  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction
 ENSG00000076984 MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7  / reaction
 ENSG00000171587 DSCAM / O60469 / DS cell adhesion molecule  / reaction






 

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