Manteia

ENSG00000088986

Homo sapiens

Features

Gene ID:	ENSG00000088986

Biological name :	DYNLL1

Synonyms :	dynein light chain LC8-type 1 / DYNLL1 / P63167

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	12
Strand:	1
Band:	q24.31
Gene start:	120469850
Gene end:	120498493

Corresponding Affymetrix probe sets:	200703_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000448834 Ensembl peptide - ENSP00000449088 Ensembl peptide - ENSP00000242577 Ensembl peptide - ENSP00000376296 Ensembl peptide - ENSP00000376297 Ensembl peptide - ENSP00000446596 Ensembl peptide - ENSP00000446614 Ensembl peptide - ENSP00000447494 Ensembl peptide - ENSP00000447907 Ensembl peptide - ENSP00000448608 NCBI entrez gene - 8655 See in Manteia. OMIM - 601562 RefSeq - NM_001037494 RefSeq - NM_001037495 RefSeq - NM_003746 RefSeq Peptide - NP_001032583 RefSeq Peptide - NP_001032584 RefSeq Peptide - NP_003737 swissprot - Q6FGH9 swissprot - F8VXI7 swissprot - F8VXL2 swissprot - P63167 swissprot - F8VRV5 Ensembl - ENSG00000088986

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dynll1	ENSDARG00000058454	Danio rerio
si:dkeyp-51b9.3	ENSDARG00000092379	Danio rerio
DYNLL1	ENSGALG00000020999	Gallus gallus
BC048507	ENSMUSG00000064063	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2	ENSG00000264364	93
DNAL4 / O96015 / dynein axonemal light chain 4	ENSG00000100246	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR001372	Dynein light chain, type 1/2
IPR019763	Dynein light chain, type 1/2, conserved site
IPR037177	Dynein light chain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000086	G2/M transition of mitotic cell cycle	TAS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006888	ER to Golgi vesicle-mediated transport	TAS
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007017	microtubule-based process	IEA
biological_process	GO:0007062	sister chromatid cohesion	TAS
biological_process	GO:0007286	spermatid development	IEA
biological_process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
biological_process	GO:0010970	transport along microtubule	IBA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016236	macroautophagy	TAS
biological_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
biological_process	GO:0021762	substantia nigra development	HEP
biological_process	GO:0035735	intraciliary transport involved in cilium assembly	TAS
biological_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
biological_process	GO:0042326	negative regulation of phosphorylation	IDA
biological_process	GO:0043312	neutrophil degranulation	TAS
biological_process	GO:0050790	regulation of catalytic activity	IEA
biological_process	GO:0060271	cilium assembly	IBA
biological_process	GO:0097711	ciliary basal body-plasma membrane docking	TAS
biological_process	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS
biological_process	GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	IBA
cellular_component	GO:0000776	kinetochore	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005813	centrosome	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005868	cytoplasmic dynein complex	IDA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0005875	microtubule associated complex	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0008180	COP9 signalosome	IDA
cellular_component	GO:0016020	membrane	HDA
cellular_component	GO:0030141	secretory granule	IEA
cellular_component	GO:0030286	dynein complex	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0070821	tertiary granule membrane	TAS
cellular_component	GO:0072686	mitotic spindle	IDA
cellular_component	GO:0097542	ciliary tip	TAS
cellular_component	GO:0101003	ficolin-1-rich granule membrane	TAS
cellular_component	GO:1904115	axon cytoplasm	IEA
molecular_function	GO:0003774	motor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008092	cytoskeletal protein binding	IBA
molecular_function	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	IBA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0030235	nitric-oxide synthase regulator activity	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0045505	dynein intermediate chain binding	IBA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0051959	dynein light intermediate chain binding	IBA
molecular_function	GO:0097110	scaffold protein binding	IEA

Pathways (from Reactome)

Pathway description

Activation of BIM and translocation to mitochondria

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Macroautophagy

MHC class II antigen presentation

Separation of Sister Chromatids

Resolution of Sister Chromatid Cohesion

Regulation of PLK1 Activity at G2/M Transition

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Loss of Nlp from mitotic centrosomes

Recruitment of mitotic centrosome proteins and complexes

Loss of proteins required for interphase microtubule organization from the centrosome

Recruitment of NuMA to mitotic centrosomes

Anchoring of the basal body to the plasma membrane

Intraflagellar transport

RHO GTPases Activate Formins

Neutrophil degranulation

COPI-mediated anterograde transport

COPI-independent Golgi-to-ER retrograde traffic

Mitotic Prometaphase

AURKA Activation by TPX2

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000023287	Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1	/ reaction
ENSG00000111725	PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1	/ reaction
ENSG00000126775	ATG14 / Q6ZNE5 / autophagy related 14	/ complex / reaction
ENSG00000131791	O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2	/ reaction
ENSG00000104671	DCTN6 / O00399 / dynactin subunit 6	/ complex
ENSG00000131966	ACTR10 / Q9NZ32 / actin related protein 10 homolog	/ complex
ENSG00000088986	DYNLL1 / P63167 / dynein light chain LC8-type 1	/ complex
ENSG00000137100	DCTN3 / O75935 / dynactin subunit 3	/ complex
ENSG00000077549	CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit	/ complex
ENSG00000116489	CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1	/ complex
ENSG00000153094	O43521 / BCL2L11 / BCL2 like 11	/ complex
ENSG00000151746	BICD1 / Q96G01 / BICD cargo adaptor 1	/ complex / reaction
ENSG00000175582	RAB6A / P20340 / RAB6A, member RAS oncogene family	/ complex / reaction
ENSG00000166847	DCTN5 / Q9BTE1 / dynactin subunit 5	/ complex
ENSG00000141429	GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1	/ complex / reaction
ENSG00000177938	CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3	/ complex
ENSG00000077380	Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2	/ complex
ENSG00000110497	AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1	/ complex / reaction
ENSG00000158560	O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1	/ complex
ENSG00000204843	DCTN1 / Q14203 / dynactin subunit 1	/ complex
ENSG00000197102	Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1	/ complex
ENSG00000198898	CAPZA2 / P47755 / capping actin protein of muscle Z-line alpha subunit 2	/ complex
ENSG00000143641	GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2	/ complex / reaction
ENSG00000138107	ACTR1A / P61163 / ARP1 actin related protein 1 homolog A	/ complex
ENSG00000007168	P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1	/ complex
ENSG00000132912	DCTN4 / Q9UJW0 / dynactin subunit 4	/ complex
ENSG00000175203	DCTN2 / Q13561 / dynactin subunit 2	/ complex
ENSG00000115592	PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3	/ reaction
ENSG00000135720	O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2	/ complex
ENSG00000078142	PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3	/ complex / reaction
ENSG00000144635	Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1	/ complex
ENSG00000106617	PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2	/ reaction
ENSG00000132356	PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1	/ reaction
ENSG00000181929	P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1	/ reaction
ENSG00000123395	ATG101 / Q9BSB4 / autophagy related 101	/ reaction
ENSG00000177169	ULK1 / O75385 / unc-51 like autophagy activating kinase 1	/ reaction
ENSG00000175224	ATG13 / O75143 / autophagy related 13	/ reaction
ENSG00000126581	BECN1 / Q14457 / beclin 1	/ complex / reaction
ENSG00000196455	PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4	/ complex / reaction
ENSG00000107643	MAPK8 / P45983 / mitogen-activated protein kinase 8	/ reaction
ENSG00000162409	P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2	/ reaction
ENSG00000264364	DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr