Manteia

ENSG00000185386

Homo sapiens

Features

Gene ID:	ENSG00000185386

Biological name :	MAPK11

Synonyms :	MAPK11 / mitogen-activated protein kinase 11 / Q15759

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	22
Strand:	-1
Band:	q13.33
Gene start:	50263713
Gene end:	50270767

Corresponding Affymetrix probe sets:	206040_s_at (Human Genome U133 Plus 2.0 Array) 211499_s_at (Human Genome U133 Plus 2.0 Array) 211500_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000333685 Ensembl peptide - ENSP00000379113 Ensembl peptide - ENSP00000409136 NCBI entrez gene - 5600 See in Manteia. OMIM - 602898 RefSeq - XM_011530706 RefSeq - NM_002751 RefSeq Peptide - NP_002742 swissprot - Q15759 swissprot - F8WDP4 Ensembl - ENSG00000185386

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mapk11	ENSDARG00000045836	Danio rerio
MAPK11	ENSGALG00000040023	Gallus gallus
Mapk11	ENSMUSG00000053137	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
MAPK14 / Q16539 / mitogen-activated protein kinase 14	ENSG00000112062	71
MAPK12 / P53778 / mitogen-activated protein kinase 12	ENSG00000188130	62
MAPK13 / O15264 / mitogen-activated protein kinase 13	ENSG00000156711	59
MAPK8 / P45983 / mitogen-activated protein kinase 8	ENSG00000107643	49
MAPK10 / P53779 / mitogen-activated protein kinase 10	ENSG00000109339	49
MAPK9 / P45984 / mitogen-activated protein kinase 9	ENSG00000050748	48

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
IPR008352	Mitogen-activated protein (MAP) kinase p38-like
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	TAS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007265	Ras protein signal transduction	TAS
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0051090	regulation of DNA-binding transcription factor activity	TAS
biological_process	GO:0051149	positive regulation of muscle cell differentiation	TAS
biological_process	GO:0051403	stress-activated MAPK cascade	IDA
biological_process	GO:0060043	regulation of cardiac muscle cell proliferation	IEA
biological_process	GO:0060044	negative regulation of cardiac muscle cell proliferation	IEA
biological_process	GO:0071347	cellular response to interleukin-1	IDA
biological_process	GO:0098586	cellular response to virus	IMP
biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	TAS
biological_process	GO:2001184	positive regulation of interleukin-12 secretion	IMP
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005829	cytosol	TAS
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	TAS
molecular_function	GO:0004707	MAP kinase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

NOD1/2 Signaling Pathway

p38MAPK events

ERK/MAPK targets

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Oxidative Stress Induced Senescence

CDO in myogenesis

DSCAM interactions

VEGFA-VEGFR2 Pathway

activated TAK1 mediates p38 MAPK activation

Activation of the AP-1 family of transcription factors

KSRP (KHSRP) binds and destabilizes mRNA

Regulation of TP53 Activity through Phosphorylation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000162889	P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2	/ complex / reaction
ENSG00000034152	MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3	/ reaction
ENSG00000071564	TCF3 / P15923 / transcription factor 3	/ reaction
ENSG00000115966	ATF2 / P15336 / activating transcription factor 2	/ reaction
ENSG00000064309	CDON / Q4KMG0 / cell adhesion associated, oncogene regulated	/ complex / reaction
ENSG00000008294	SPAG9 / O60271 / sperm associated antigen 9	/ complex / reaction
ENSG00000132475	H3F3B / P84243 / H3 histone family member 3B	/ reaction
ENSG00000109819	Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha	/ reaction
ENSG00000129910	CDH15 / P55291 / cadherin 15	/ complex / reaction
ENSG00000170558	CDH2 / P19022 / cadherin 2	/ complex / reaction
ENSG00000044115	CTNNA1 / P35221 / catenin alpha 1	/ complex / reaction
ENSG00000140299	BNIP2 / Q12982 / BCL2 interacting protein 2	/ complex / reaction
ENSG00000144857	BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated	/ complex / reaction
ENSG00000081189	MEF2C / Q06413 / myocyte enhancer factor 2C	/ complex / reaction
ENSG00000097007	ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ complex / reaction
ENSG00000066032	CTNNA2 / P26232 / catenin alpha 2	/ complex / reaction
ENSG00000068305	MEF2A / Q02078 / myocyte enhancer factor 2A	/ complex / reaction
ENSG00000183598	Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d	/ reaction
ENSG00000114738	Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3	/ complex / reaction
ENSG00000168036	CTNNB1 / P35222 / catenin beta 1	/ complex / reaction
ENSG00000088247	KHSRP / Q92945 / KH-type splicing regulatory protein	/ reaction
ENSG00000100784	O75582 / RPS6KA5 / ribosomal protein S6 kinase A5	/ reaction
ENSG00000276180	P62805 / HIST1H4I / histone cluster 1 H4 family member i	/ reaction
ENSG00000275714	P68431 / HIST1H3A / histone cluster 1 H3 family member a	/ reaction
ENSG00000108984	MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6	/ reaction
ENSG00000089022	Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr