ENSG00000114738


Homo sapiens

Features
Gene ID: ENSG00000114738
  
Biological name :MAPKAPK3
  
Synonyms : MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.2
Gene start: 50611520
Gene end: 50649297
  
Corresponding Affymetrix probe sets: 202787_s_at (Human Genome U133 Plus 2.0 Array)   202788_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410970
Ensembl peptide - ENSP00000394894
Ensembl peptide - ENSP00000478922
Ensembl peptide - ENSP00000396467
Ensembl peptide - ENSP00000402045
Ensembl peptide - ENSP00000350639
NCBI entrez gene - 7867     See in Manteia.
OMIM - 602130
RefSeq - NM_004635
RefSeq - NM_001243925
RefSeq - NM_001243926
RefSeq Peptide - NP_001230854
RefSeq Peptide - NP_001230855
RefSeq Peptide - NP_004626
swissprot - Q16644
swissprot - C9J8E1
swissprot - A0A024R2W7
swissprot - H7C0G6
swissprot - C9JPW3
Ensembl - ENSG00000114738
  
Related genetic diseases (OMIM): 617111 - ?Macular dystrophy, patterned, 3, 617111
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk3ENSDARG00000111612Danio rerio
 MAPKAPK3ENSGALG00000002283Gallus gallus
 Q3UMW7ENSMUSG00000032577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2ENSG0000016288968
Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5ENSG0000008902240
MKNK2 / Q9HBH9 / MAP kinase interacting serine/threonine kinase 2ENSG0000009987531
MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1ENSG0000007927730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002224 toll-like receptor signaling pathway ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0044351 macropinocytosis ISS
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
Oxidative Stress Induced Senescence
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
Show

 HP:0000510 Retinitis pigmentosa "Hereditary degeneration and atrophy of the retina." [HPO:curators]
Show

 HP:0007663 Decreased central vision 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / complex / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr