ENSGALG00000035950


Gallus gallus

Features
Gene ID: ENSGALG00000035950
  
Biological name :NGFR
  
Synonyms : NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16
  
Possible biological names infered from orthology : nerve growth factor receptor / P08138
  
Species: Gallus gallus
  
Chr. number: 27
Strand: -1
Band:
Gene start: 3423153
Gene end: 3434589
  
Corresponding Affymetrix probe sets: Gga.6245.2.S1_at (Chicken Array)   GgaAffx.11269.1.S1_at (Chicken Array)   GgaAffx.7932.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046489
NCBI entrez gene - 425805     See in Manteia.
RefSeq - NM_001146133
RefSeq Peptide - NP_001139605
swissprot - P18519
Ensembl - ENSGALG00000035950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfraENSDARG00000088708Danio rerio
 ngfrbENSDARG00000089223Danio rerio
 NGFRENSG00000064300Homo sapiens
 NgfrENSMUSG00000000120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nradd* / Q8CJ26* / Death domain-containing membrane protein NRADD *ENSGALG0000004487431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR022325  Tumour necrosis factor receptor 16


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010977 negative regulation of neuron projection development IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005035 death receptor activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043121 neurotrophin binding IDA
 molecular_functionGO:0048406 nerve growth factor binding IDA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002708 LINGO1 / Q50L44 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q9D1T0* / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / complex / reaction
 ENSGALG00000009073 PSEN2 / presenilin 2 / P49810*  / reaction
 ENSGALG00000008443 ARHGDIA / rho GDP-dissociation inhibitor 1 / P52565* / Q99PT1* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSGALG00000007732 RTN4R* / Q99PI8* / Q9BZR6* / reticulon 4 receptor*  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000016427 ADAM17 / disintegrin and metalloproteinase domain-containing protein 17 precursor / P78536* / Q9Z0F8* / ADAM metallopeptidase domain 17* / Disintegrin and metalloproteinase domain-containi...  / reaction
 ENSGALG00000009320 PSEN1 / Q4JIM4 / Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / P49768* / P49769* / presenilin 1*  / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex / reaction
 ENSGALG00000005594 OMG / oligodendrocyte myelin glycoprotein / P23515*  / complex / reaction
 ENSGALG00000009364 PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*  / complex / reaction
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000045163 APH1A / aph-1 homolog A, gamma-secretase subunit / Q8BVF7* / Q96BI3* / Gamma-secretase subunit APH-1A *  / reaction






 

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