ENSDARG00000079123


Danio rerio

Features
Gene ID: ENSDARG00000079123
  
Biological name :ikbkb
  
Synonyms : ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  
Possible biological names infered from orthology : inhibitor of kappaB kinase beta / inhibitor of nuclear factor kappa B kinase subunit beta / O14920
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 2319091
Gene end: 2406699
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000117685
NCBI entrez gene - 563560     See in Manteia.
RefSeq - NM_001123265
RefSeq Peptide - NP_001116737
swissprot - B0R199
ZFIN ID - ZDB-GENE-071115-2
Ensembl - ENSDARG00000079123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IKBKBENSGALG00000031832Gallus gallus
 IKBKBENSG00000104365Homo sapiens
 IkbkbENSMUSG00000031537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSDARG0000001166246
ulk2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSDARG0000009720519
ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*ENSDARG0000007448118
tbk1 / TANK-binding kinase 1 / Q9UHD2*ENSDARG0000010309518
ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*ENSDARG0000007060617
ulk1a / unc-51 like autophagy activating kinase 1a / ULK1* / O75385* / unc-51 like kinase 1* / unc-51 like autophagy activating kinase 1*ENSDARG0000006251816
ulk3 / unc-51 like kinase 3 / Q6PHR2*ENSDARG000001016618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IBA
 cellular_componentGO:0008385 IkappaB kinase complex IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / reaction
 ENSDARG00000031954 rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex / reaction
 ENSDARG00000061710 map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / reaction
 ENSDARG00000059871 A9JTG5 / shrprbck1r / sharpin and rbck1 related / Q9H0F6* / Q91WA6* / SHARPIN* / SHANK associated RH domain interactor*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / complex / reaction
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000060058 cylda / cylindromatosis (turban tumor syndrome), a / CYLD* / Q80TQ2* / Q9NQC7* / CYLD lysine 63 deubiquitinase* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / reaction
 ENSDARG00000076995 sharpin / SHANK-associated RH domain interacting protein / Q91WA6* / Q9H0F6* / SHANK associated RH domain interactor*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / reaction






 

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