ENSDARG00000076995


Danio rerio

Features
Gene ID: ENSDARG00000076995
  
Biological name :sharpin
  
Synonyms : SHANK-associated RH domain interacting protein / sharpin
  
Possible biological names infered from orthology : Q91WA6 / Q9H0F6 / SHANK associated RH domain interactor
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 354424
Gene end: 364839
  
Corresponding Affymetrix probe sets: Dr.14025.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000128247
NCBI entrez gene - 793673     See in Manteia.
RefSeq - XM_001333445
swissprot - X1WDE8
ZFIN ID - ZDB-GENE-101223-1
Ensembl - ENSDARG00000076995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9H0F6ENSG00000179526Homo sapiens
 Q91WA6ENSMUSG00000022552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A9JTG5 / shrprbck1r / sharpin and rbck1 related / Q9H0F6* / Q91WA6* / SHARPIN* / SHANK associated RH domain interactor*ENSDARG0000005987146
rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*ENSDARG0000003195417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR011993  PH-like domain superfamily
 IPR026168  SHARPIN
 IPR029071  Ubiquitin-like domain superfamily
 IPR031912  Sharpin, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0048592 eye morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 biological_processGO:0097039 protein linear polyubiquitination IBA
 cellular_componentGO:0071797 LUBAC complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle malformed , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000031954 rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr